Antibodies against Alpha‐Fodrin Are Associated with Sicca Syndrome in the General Population

Abstract

The significance of antibodies against alpha-fodrin compared to antibodies against Ro (SSA) as markers of Sjögren's syndrome has been controversially discussed. We therefore compared the association of alpha-fodrin and Ro antibodies with dry eyes and dry mouth in the general population. In 168 "normal" participants, the prevalence of IgA antibodies against alpha-fodrin was 5% and of IgG antibodies against alpha-fodrin was 3%. IgA antibodies against alpha-fodrin were present in 3 of 4 and IgG antibodies against alpha-fodrin in 2 of 4 participants with the combination of dry eyes and dry mouth (P = 0.0002 and 0.005). Only one participant had antibodies against Ro and had dry eyes but normal saliva production. Antibodies against alpha-fodrin are associated with sicca syndrome and may be valuable diagnostic markers in patients with Sjögren's syndrome lacking Ro antibodies.

Diagnose und Therapie des Sjögren-Syndroms

“…Im Serum nachweisbare Ro(SSA)und La(SSB)-Antikörper sind mit dem Sjögren-Syndrom assoziierte Autoantikörper, wobei Ro-Antikörper mit maximal 60 % eine höhere Sensitivität und La-Antikörper mit über 90 % die höhere Spezifität aufweisen [22,31]. Der Nachweis von Antikörpern gegen α-Fodrin hat bei fehlendem Nachweis von Ro-und La-Antikörpern diagnostische Bedeutung, wird aber nicht in allen Laboratorien angeboten [45] application of pilocarpine and non-steroidal anti-rheumatic drugs are usually sufficient to cope with the clinical condition. Refractory inflammatory joint disease, pulmonary and central nervous system involvement as well as small vessel vasculitis require immunosuppressive therapy.…”

Influence of STAT4 Polymorphism in Primary Sjögren’s Syndrome

“…The Journal of on July 2, 2015 -Published by www.jrheum.org Downloaded from Palomino-Morales, et al: STAT4 polymorphism in SS Demographic characteristics of the patients and controls in each population have been described [15][16][17] .…”

Frühe immunsuppressive Therapie des Sjögren-Syndroms – Pro und Kontra

“…Die subjektive Angabe einer Augenund Mundtrockenheit muss nicht zwingend mit objektiven Kriterien einer Augentrockenheit einhergehen. Umgekehrt k ö nnen okul ä re oder orale Symptome trotz z. T. deutlich verminderter Tr ä nen-oder Speichelproduktion fehlen [30] . Neben den Symptomen der Augen-und Mundtrockenheit sollte daher geh ä uft auf die sog.…”