Antibodies against bovine herpesvirus 4 are highly prevalent in wild African buffaloes throughout eastern and southern Africa

Dewals, Benjamin G; Gillet, Laurent; Gerdes, T.; Taracha, Evans; Thiry, Étienne; Vanderplasschen, Alain

doi:10.1016/j.vetmic.2005.08.006

Cited by 19 publications

(16 citation statements)

References 24 publications

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“…The natural host of the virus is primarily cattle, but several ruminant and non-ruminant species are susceptible to BoHV-4 infection (10, 11). Wild African buffaloes ( Syncerus caffer ) can be considered as a reservoir species, in which the virus is highly prevalent (11, 12). This virus was first isolated in Europe from cattle with respiratory diseases (13) and later in the United States (14).…”

Section: Introductionmentioning

confidence: 99%

Whole Genome Sequencing of a Canadian Bovine Gammaherpesvirus 4 Strain and the Possible Link between the Viral Infection and Respiratory and Reproductive Clinical Manifestations in Dairy Cattle

et al. 2017

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Bovine gammaherpesvirus 4 (BoHV-4) is a herpesvirus widespread in cattle populations, and with no clear disease association. Its genome contains a long unique coding region (LUR) flanked by polyrepetitive DNA and 79 open reading frames (ORFs), with unique 17 ORFs, named Bo1 to Bo17. In 2009, a BoHV-4 strain was isolated (FMV09-1180503: BoHV-4-FMV) from cattle with respiratory disease from Quebec, Canada, and its LUR was sequenced. Despite the overall high similarity, BoHV-4-FMV had the most divergent LUR sequence compared to the two known BoHV-4 reference strain genomes; most of the divergences were in the Bo genes and in the repeat regions. Our phylogenetic analysis based on DNA polymerase and thymidine kinase genes revealed that virus isolate was BoHV-4 gammaherpesvirus and clustered it together with European BoHV-4 strains. Because BoHV-4-FMV was isolated from animals presenting respiratory signs, we have updated the BoHV-4 Canadian cattle seroprevalence data and tried to find out whether there is a link between clinical manifestation and BoHV-4 seropositivity. An indirect immunofluorescence assay (IFA) was performed with nearly 200 randomized sera of dairy cattle from two Canadian provinces, Quebec (n = 100) and Ontario (n = 91). An additional set of sera obtained from Quebec, from the healthy (n = 48) cows or from the animals experiencing respiratory or reproductive problems (n = 75), was also analyzed by IFA. BoHV-4 seroprevalence in Canadian dairy cattle was 7.9% (Quebec: 6% and Ontario: 9.9%). Among animals from the Quebec-based farms, diseased animals showed higher BoHV-4 seropositivity than healthy animals (P < 0.05), with a significant 2.494 odds ratio of being seropositive in sick compared to healthy animals. Although there is no established direct link between BoHV-4 and specific diseases, these seroprevalence data suggest the possible involvement of BoHV-4 in dairy cattle diseases.

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Section: Introductionmentioning

confidence: 99%

Whole Genome Sequencing of a Canadian Bovine Gammaherpesvirus 4 Strain and the Possible Link between the Viral Infection and Respiratory and Reproductive Clinical Manifestations in Dairy Cattle

et al. 2017

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“…Besides cattle, BoHV-4 has also been detected in a variety of ruminants. In particular, BoHV-4 seems to be highly prevalent among wild African buffalo ( Syncerus caffer ) which could be considered as the natural reservoir of the virus [8-10]. Overall, more than 40 BoHV-4 strains have been isolated across the world.…”

Section: Introductionmentioning

confidence: 99%

Sequencing of bovine herpesvirus 4 v.test strain reveals important genome features

Palmeira

Machiels

Lété

et al. 2011

Virol J

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BackgroundBovine herpesvirus 4 (BoHV-4) is a useful model for the human pathogenic gammaherpesviruses Epstein-Barr virus and Kaposi's Sarcoma-associated Herpesvirus. Although genome manipulations of this virus have been greatly facilitated by the cloning of the BoHV-4 V.test strain as a Bacterial Artificial Chromosome (BAC), the lack of a complete genome sequence for this strain limits its experimental use.MethodsIn this study, we have determined the complete sequence of BoHV-4 V.test strain by a pyrosequencing approach.ResultsThe long unique coding region (LUR) consists of 108,241 bp encoding at least 79 open reading frames and is flanked by several polyrepetitive DNA units (prDNA). As previously suggested, we showed that the prDNA unit located at the left prDNA-LUR junction (prDNA-G) differs from the other prDNA units (prDNA-inner). Namely, the prDNA-G unit lacks the conserved pac-2 cleavage and packaging signal in its right terminal region. Based on the mechanisms of cleavage and packaging of herpesvirus genomes, this feature implies that only genomes bearing left and right end prDNA units are encapsulated into virions.ConclusionsIn this study, we have determined the complete genome sequence of the BAC-cloned BoHV-4 V.test strain and identified genome organization features that could be important in other herpesviruses.

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“…It is possible that the two animals that were sero-positive in the pre-trial sample could simply be the result of infection with viruses that cross-react with the ELISA used here. While it is likely that other MCF virus infections would induce cross-reactive antibodies detectable by AlHV-1 ELISA, it has also been reported that bovine herpesvirus-4 (BoHV-4) antibodies can detect AlHV-1 infected cells by immunofluorescence (Dewals et al, 2005). However previous testing did not show cross-reactivity with BoHV-4 specific sera in the direct MCF ELISA (Fraser et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen ® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge

Lankester

Lugelo

Werling

et al. 2016

Veterinary Microbiology

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Antibodies against bovine herpesvirus 4 are highly prevalent in wild African buffaloes throughout eastern and southern Africa

Cited by 19 publications

References 24 publications

Whole Genome Sequencing of a Canadian Bovine Gammaherpesvirus 4 Strain and the Possible Link between the Viral Infection and Respiratory and Reproductive Clinical Manifestations in Dairy Cattle

Whole Genome Sequencing of a Canadian Bovine Gammaherpesvirus 4 Strain and the Possible Link between the Viral Infection and Respiratory and Reproductive Clinical Manifestations in Dairy Cattle

Sequencing of bovine herpesvirus 4 v.test strain reveals important genome features

The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen ® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge

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