2021
DOI: 10.1186/s12903-021-01712-y
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Antibodies against citrullinated proteins in relation to periodontitis with or without rheumatoid arthritis: a cross-sectional study

Abstract: Background Previous studies have reported conflicting findings between serum anti-citrullinated protein antibodies (ACPA) levels in rheumatoid arthritis (RA) participants with and without periodontitis (Pd). This study aimed to analyse possible correlations between serum ACPA levels and clinical parameters in Pd and RA participants. Methods Full mouth periodontal examination (probing pocket depth, clinical attachment levels, gingival bleeding index… Show more

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Cited by 7 publications
(5 citation statements)
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“…In this population 27.9% were ACPA-positive, supporting the involvement of PD in ACPA production [56]. However, when serum levels were analyzed for ACPA quantification in subjects with or without RA, and with or without PD, no correlation was found between ACPA and the clinical parameters of PD [57].…”
Section: Clinical Evidence Of the Relationship Between Ra And Pdmentioning
confidence: 65%
“…In this population 27.9% were ACPA-positive, supporting the involvement of PD in ACPA production [56]. However, when serum levels were analyzed for ACPA quantification in subjects with or without RA, and with or without PD, no correlation was found between ACPA and the clinical parameters of PD [57].…”
Section: Clinical Evidence Of the Relationship Between Ra And Pdmentioning
confidence: 65%
“…Sixty-three clinical studies were conducted between 2013 and 2022 to assess the role of periodontitis and/or periodontopathic bacteria in the pathogenesis of RA [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , [87] , [88] , [89] , [90] , [91] , [92] , [93] , [94] , [95] , [96] , [97] , [98] , [99] , [100] , [101] , [102] , [103] , [104] , [105] , [106] , [107] , [108] , [109] , [110] , [111] , [112] , [113] , [114] , [115] , [116] , [117] , [118] , [119] , [120] , [121] , [122] , [123] , [124] , [125] , [126] , [127] , [128] , [129] , [130] , [131] , [132] , [133] , [134] , [135] . Of these studies, 30 considered periodontitis and of these, 28 reported a s...…”
Section: Publications 2013–2022mentioning
confidence: 99%
“…In addition, bacteremia caused by periodontal pathogens into the blood can induce the production of acute-phase proteins and antibodies, as well as the activation of macrophages (Nguyen et al, 2015). Research Periodontal non-surgical treatment (SRP) can significantly reduce the serum levels of ACPA, CRP, ESR, IL-6, TNFα, and 28 disease activity scores in patients with RA and periodontitis, and reduced PD and sulcus bleeding index (SBI; Ding et al, 2022;González-Febles & Sanz, 2021;Lew et al, 2021). And PD, CAL, GI, and BOP were reduced in RA patients with periodontitis when treated with conventional synthetic antirheumatic drugs, anti-B-lymphocyte drugs, anti-IL-6R drugs, and JAK inhibitors (González-Febles & Sanz, 2021; Zhang et al, 2021).…”
Section: Do Patients With Rheumatoid Arthritis Need Regular Periodont...mentioning
confidence: 99%