Antibodies against human herpesvirus 8 in subjects with non-venereal dermatological conditions

Masini, Cinzia; Abeni, Damiano; Cattaruzza, Maria Sofia; Capuano, M.; Pedicelli, Cristina; Cerimele, Francesca; Pasquini, Paolo; Cerimele, D; Fadda, Giovanni; Cattani, Paola

doi:10.1111/j.1365-2133.2000.03699.x

Cited by 8 publications

(3 citation statements)

References 33 publications

(86 reference statements)

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“…This study indicates that HHV-8 infection is present among Tobago women at a frequency similar to that previously reported in men [Hoffman et al, 2004;Plancoulaine et al, 2004;Serraino et al, 2006;Engels et al, 2007]. The seropositivity rate observed among these women is comparable to rates found among women in the Mediterranean area [Masini et al, 2000;Cattani et al, 2003;Tanzi et al, 2005]. As for KS, this incidence has been reported to range from 0.2 to 2.8 per 100,000 population per year among women in the Mediterranean region [Davidovici et al, 2001;Vitale et al, 2001;Tanzi et al, 2005].…”

Section: Discussionsupporting

confidence: 85%

Human herpesvirus 8 seroprevalence among Tobago women and the role of sexual lifestyle behavior

McDonald

Ragin

Jenkins

et al. 2008

Journal of Medical Virology

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Human herpesvirus 8 (HHV-8) infection is present in 22.9% of Tobago men. However, seroprevalence and modes of transmission of HHV-8 among Tobago women are not known. HHV-8 seropositivity rates in Tobago women were examined and compared rates to Tobago men of similar ages. To assess possible modes of transmission, sexual behavior among Tobago women was examined to determine its association with HHV-8 seropositivity.A cross-sectional study was conducted in 213 Tobago women, ages 18-65 years, who participated in the Tobago Cervical and Oral Cancer Screening Study. HHV-8 seropositivity was determined by a monoclonal immunofluorescence assay. Age-specific rates were compared to those previously observed in men. Logistic regression analyses were performed to determine the association between HHV-8 seropositivity and sexual behavior among the women.HHV-8 seroprevalence among Tobago women was 14.1% (95% C.I., 10 -19%), with no significant differences with men of similar age (p-value = .741). Age ≤ 17 years at first sexual intercourse was found to have a minimal significant association with HHV-8 seropositivity (O.R. = 2.51, 95% C.I. = 1.09-5.78) in women.HHV-8 age-specific rates were similar between genders. Sexual activity may not be a major contributor to HHV-8 infection among Tobago women.

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Section: Discussionsupporting

confidence: 85%

Human herpesvirus 8 seroprevalence among Tobago women and the role of sexual lifestyle behavior

McDonald

Ragin

Jenkins

et al. 2008

Journal of Medical Virology

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“…The observed 12 to 26% increase in rates of seropositivity following transplantation is paralleled by the age-related increase in prevalence observed in the control group and by previous reports pointing in the same direction (14,15). This suggests that seroconversion due to transplantation may be relatively rare.…”

Section: Discussionsupporting

confidence: 63%

“…This rate was statistically indistinguishable from the rate (14.9%) observed in controls. The observed rate of seropositivity in pretransplant patients was higher than rates reported in other European countries (8,19) and can be explained by the higher-thanaverage HHV-8 seroprevalence in the general population of central and southern Italy (5,14,22,23). The data suggest that HHV-8 seroprevalence is unaffected by pretransplant therapeutic regimens.…”

Section: Discussioncontrasting

confidence: 50%

Kaposi's Sarcoma Associated with Previous Human Herpesvirus 8 Infection in Kidney Transplant Recipients

et al. 2001

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This study investigates the prevalence of human herpesvirus 8 (HHV-8) infection in kidney transplant patients, evaluating the risk of HHV-8 transmission via transplantation and the association between pre-and posttransplantation HHV-8 infection and the subsequent development of Kaposi's sarcoma (KS). Immunofluorescence and an enzyme immunoassay were used to determine HHV-8 seroprevalence in 175 patients awaiting kidney transplantation and 215 controls who were attending our clinic for other reasons. All patients in the study came from central or southern Italy. Seroprevalence was similar in both groups (14.8 versus 14.9%), with no significant difference between the rates for male and female patients. Of the 175 patients, 100 were tested for anti-HHV-8 antibodies at various times during follow-up. During follow-up, seroprevalence increased from 12% on the date of transplantation to 26%. This increase was paralleled by an age-related increase in seroprevalence in the control group. During follow-up from 3 months to 10 years after transplantation, KS was diagnosed in seven patients (4.0%). Six of these patients were positive for HHV-8 prior to transplantation. Overall, 23.0% of patients who were HHV-8 positive before transplantation developed KS, whereas only 0.7% of seronegative patients developed the disease (relative risk, 34.4; 95% confidence interval, 4.31 to 274.0). This finding suggests that the key risk factor for KS is infection prior to transplantation and that antibody detection in patients awaiting transplantation could be useful in identifying patients at high risk for KS. In patients from geographic areas with a high prevalence of HHV-8, serological tests on donors may be less important.

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Viral diseases

Weedon

2010

Weedon's Skin Pathology

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Antibodies against human herpesvirus 8 in subjects with non-venereal dermatological conditions

Cited by 8 publications

References 33 publications

Human herpesvirus 8 seroprevalence among Tobago women and the role of sexual lifestyle behavior

Human herpesvirus 8 seroprevalence among Tobago women and the role of sexual lifestyle behavior

Kaposi's Sarcoma Associated with Previous Human Herpesvirus 8 Infection in Kidney Transplant Recipients

Viral diseases

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