Antibodies against oxidized LDL and atherosclerosis in rheumatoid arthritis patients treated with biological agents: a prospective controlled study

Papamichail, G. V.; Georgiadis, A. N.; Tellis, C. C.; Rapti, I.; Markatseli, T. E.; Xydis, V. G.; Tselepis, A. D.; Drosos, A. A.; Voulgari, P. V.

doi:10.1007/s10067-023-06744-z

Cited by 2 publications

(1 citation statement)

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“…Among antibodies implicated in the pathogenesis of atherosclerosis in RA, anti-ox-LDL antibodies [ 98 ], which cross-react with antiphospholipids and the anti-ox-LDL/β2GPI complex, are all increased both in SLE and RA [ 99 ]. This evidence offered a first explanation for the increased cardiovascular risk in autoimmunity [ 100 ].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Crosstalk between Inflammation and Atherosclerosis in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Is There a Common Basis?

Sircana,

Erre,

Castagna

et al. 2024

Life

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Cardiovascular disease is the leading cause of morbidity and mortality in patients with rheumatoid arthritis and systemic lupus erythematosus. Traditional cardiovascular risk factors, although present in lupus and rheumatoid arthritis, do not explain such a high burden of early cardiovascular disease in the context of these systemic connective tissue diseases. Over the past few years, our understanding of the pathophysiology of atherosclerosis has changed from it being a lipid-centric to an inflammation-centric process. In this review, we examine the pathogenesis of atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis, the two most common systemic connective tissue diseases, and consider them as emblematic models of the effect of chronic inflammation on the human body. We explore the roles of the inflammasome, cells of the innate and acquired immune system, neutrophils, macrophages, lymphocytes, chemokines and soluble pro-inflammatory cytokines in rheumatoid arthritis and systemic lupus erythematosus, and the roles of certain autoantigens and autoantibodies, such as oxidized low-density lipoprotein and beta2-glycoprotein, which may play a pathogenetic role in atherosclerosis progression.

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Section: Rheumatoid Arthritismentioning

confidence: 99%