Antibodies in Human Sera to Stratum corneum

The Occurrence of Antibodies to Stratum corneum in Man

“…The titres ranged from 64 to 2,048 with mode titres of 256 to 512. The greatest activity was due to yM, consistent with previous findings [13], These results show a rather wide quantitative variation of antibodies to stratum corneum among normal adults.…”

“…The fractions obtained were then tested for adherence activity. Consistent with previous findings in adult sera [13,14], adherence activity was demonstrated in fractions containing low molecular weight yglobulins with a sedimentation rate less than albumin. The reactivity of these antibodies was unaffected by treatment with ME.…”

“…The data obtained in this and previous studies [13,14,15] are compatible with the assumption of a normal autoimmune state in volving an intercellular antigen in stratum corneum. Hence, it is difficult to avoid speculating whether this particular state might be involved in the normal desquamation process which still remains an enigma.…”

“…These antibodies are of the yG class as judged from the result of experiments using fractions obtained by gel filtration and ultracentrif ugation of pooled cord serum. In addition, low molecular weight antibodies, approximately 3 S, with similar specificity were demonstrat-cd consistent with earlier findings with human adult sera [13,14]. Similar to yG globulins, the low molecular weight antibodies are resistant to treatment with ME.…”

“…These antibodies belong to the yM and yG classes of immunoglobulins [13]. Low molecular weight antibodies, approximate ly 3 S, with similar specificity have also been described [14].…”