Antibodies, prophylaxis, transmission

Lutgen, Pierre

doi:10.15406/ppij.2018.06.00155

Cited by 4 publications

(4 citation statements)

References 41 publications

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“…44,45 If silica particles truly have such a dramatic effect on sporozoite invasion, on drug efficacy, on infected erythrocytes and on gametocytes one may wonder why all the laboratories desperately looking for a solution to the alarming malaria catastrophy ignored this possibility. May be because all studies are based on in vitro efficiencies of potential antimalarials against parasites.…”

Section: Resultsmentioning

confidence: 99%

Silica particles inhibit sporozoite invasion, promote IgE, inhibit CYP3A4 and provoke bursting of infected erythrocytes

Lutgen¹

2018

PPIJ

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Silica may boost the immune system and stimulate IgE production. This effect is known since 40 years. IgE is probably the most important item in acquired humoral activity against malaria.2-7 A single dose of standard quartz with particle size <5μm is able to stimulate in Balb/c mice the production of IgE and IgG1 antibody. Silica in plants and in ArtemisiaThis mineral has barely been studied in plants. Plants take up silicon as mono-silicic acid and later it is deposited in its polymerized form as amorphous hydrated silica. Major silica depositions occur in root endodermis, leaf epidermal cells and trichomes. The ability of a plant to accumulate Si varies greatly between species. It is up to 2% in wheat, rice, oats, close to 0 % in flowers, and intermediate in kitchen and medicinal herbs: 0.4 % in spinach, 0,1 in ginseng, 0.32%, in parsley, 0.56 in salvia, 0,56 in tilia, 0.26 % in dill, 0,67 in inula, 0,6 in hibiscus, 0.61% in mint, 0.35% in Artemisia annua, 0.22% in Artemisia absinthium, 0.57% in Artemisia frigida, but only 0.002% in Artemisia maritima. Horsetail (Equisetum arvense) and nettle (Urtica dioica) containing 1.1% silica were used in Europe against malaria. [9][10][11][12][13] In many plants silica is present in the form of phytoliths in cell walls for their strenghtening. Families with high phytolith production are Acanthaceae, Aceraceae, Annonaceae, Asteraceae, Artemisia tridentata and Artemisia spicata for example contain phytoliths.

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Section: Resultsmentioning

confidence: 99%

Silica particles inhibit sporozoite invasion, promote IgE, inhibit CYP3A4 and provoke bursting of infected erythrocytes

Lutgen¹

2018

PPIJ

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“…IgE is probably the most important item in acquired humoral activity against malaria. [141][142][143][144] A single dose of standard quartz with particle size <5μm is able to stimulate in Balb/c mice the production of IgE and IgG1 antibody. 145 Silica particles are retained for over 30 days in the tissues because of the endocytosis by macrophages.…”

Section: The Role Of Artemisiasmentioning

confidence: 99%

An unexpected, revolutionary property of Artemisia infusions: immunoglobulins in the skin lead to a longlasting prophylaxis

Munyangi¹,

Gisenya²,

Ogwang³

et al. 2020

PPIJ

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Naturally acquired immunity to malaria is a known phenomenon. But little is known about the underlying mechanisms. The majority of adults in sub-Saharan Africa rarely experience overt disease, despite they have a population of parasites in their blood that could prove lethal to a malaria-naïve visitor. The use of Artemisia herbal medicine is spreading in many African countries, in schools, health centers. It was shown 10 years ago in Uganda that regular drinking of infusions from Artemisia plants had a strong prophylactic effect. We were of the belief that this prophylaxis was going to last for a few days, maybe a few weeks. Over the last 2 months we received several surprising inputs indicating that this prophylaxis was lasting for months, even years. But more recently several partners also report that when Artemisia infusions or capsules have been used during 7 days to cure a malaria infection, the people having used this short-term treatment also experience a long-lasting prophylaxis. The most interesting research lead is that specific IgEs induced by Artemisia consumption remain for months in the skin. In this review paper we present several hypotheses to explain this revolutionary property of Artemisia plants, and more particularly Artemisia afra used since generations in many African countries against tropical diseases.

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“…IgE containing immune complexes are known to give rise to monocyte activation via the NO transduction pathway. 39 Intravenous administration of human immunoglobulin increases platelet counts. The effect is dose dependent and permits to correct thrombocytopenia.…”

Section: Immunoglobulinsmentioning

confidence: 99%