Antibodies to APC Virus Type 8 in Epidemic Keratoconjunctivitis.

Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D

“…Infections likely due to adenovirus were originally described in the 1880s but not formally associated with a specific viral etiology until the early 1950s, following the first identification of the adenovirus. A group of viruses isolated from human adenoids and tonsils, and from pharyngeal and conjunctival secretions obtained from acute infections, was initially characterized as adenoidal–pharyngeal–conjunctival viruses . In an attempt to isolate ‘the virus of the common cold’, Wallace Rowe et al .…”

“…However, a few specific types within HAdV‐D are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection. The major EKC pathogens are HAdV‐D8, 37, 53, 54, 56, and 64 , with three of these identified in the last decade. Despite the continued emergence of new viruses, the molecular mechanisms that drive recombination and adenovirus ontogeny are not precisely known.…”

Neutralizing Antibody Against Infectious Canine Hepatitis Virus in Veterinary Workers'Sera (ICHV)

“…Because of this, ICHV neutralizing antibody can be distinguislhed frolm Ad-8 antilbody by testing a serum for neutralizing activity against Ad-8. Antibody to Ad-8 is nare in the North American population and is usually associated with a history of w x t e keratoconjunativitis (9). tion (veterinary workers, 46% ; nonveterinary workers, 3 …”

A Study of the Relationship Between Adenovirus and Epidemic Keratoconjunctivitis

“…Kumamoto. In addition to the isolations of adenovirus Type 8 from typical cases, the close associa¬ tion of this virus with EKC was indicated by the serological studies of Jawetz et al 6 Ninety-four per cent of persons with a recent history of EKC from America, Europe, and the Orient had neutralizing antibodies against adenovirus Type 8 in their convalescent serum at a dilution of 1:10 or greater. By contrast, about 7% of per¬ sons from the same areas having no history of EKC showed such a titer.…”