Antibodies to cardiac tissue in acute ischemic heart disease

Heine, W; Friedman, Herman; Mandell, Morton S.; Goldberg, Harry

doi:10.1016/0002-9149(66)90374-2

Cited by 36 publications

(7 citation statements)

References 11 publications

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“…The anti-heart muscle antibody screening was thought to be a reliable marker, but it is realized that antibodies are not present in all patients with PMIS and can be seen in many other cardiac conditions. 4,5 And it is known that the antigen made from human infarct myocardium is more sensitive than that from the intact heart of other animals. s In our hospital we used the antigen made from rat myocardium, and that might be one reason for the negative result in our patient.…”

Section: Discussionmentioning

confidence: 99%

Positive indium-111 leukocyte imaging in post myocardial infarction syndrome

et al. 1990

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The diagnosis of post myocardial infarction syndrome (PMIS) is sometimes difficult because of the absence of a specific test. We report a 68-year-old man with PMIS who had a persistent accumulation of indium-111 oxine labeled leukocytes in the infarcted myocardium for 1 month. The uptake of leukocytes preceded the appearance of the main symptoms and disappeared with the clinical improvement after the therapy with steroids. Leukocyte imaging has a potential as a useful tool for early diagnosis, evaluation of therapy and assessing the mechanism of PMIS.

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Section: Discussionmentioning

confidence: 99%

Positive indium-111 leukocyte imaging in post myocardial infarction syndrome

et al. 1990

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“…Of 4 patients with the intermediate coronary syndrome, 3 showed significant leucocyte migration inhibition (mean 26 ± 6%). Humoral antibodies have been found in 42 to 63 per cent of cases with angina pectoris Heine et al, 1966;Strausz and Dobias, 1967;Das et al, 1974). These observations indicate release of cardiac antigens in such patients, which may be the result of necrosis of myocardial fibres (Hurst et al, 1974).…”

Section: Discussionmentioning

confidence: 99%

“…Humoral autoantibodies have been widely studied in ischaemic heart disease Ehrenfeld et al, 1961;Van der Geld, 1964;Heine et al, 1966;Strausz and Dobias, 1967;Sharma et al, 1970). These antibodies are cytotoxic to myocardial cells grown in tissue culture (Lotta, 1958; Thompson and Halbert, 1971) and to myocardium on passive transfer in experimental animals (Chaturvedi and Mehrotra, 1967a).…”

mentioning

confidence: 99%

Leucocyte migration inhibition test in cases of ischaemic heart disease.

Sharma¹,

Ahuja²,

Op³

et al. 1978

Heart

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SUMMARY Cases of ischaemic heart disease have been studied for the cell-mediated immune response against human heart antigen by using the leucocyte migration inhibition test. In 30 cases of acute myocardial infarction, the leucocyte migration inhibition values started increasing from the first week reaching a peak in 3 to 4 weeks and then declining but still above control values 12 months after infarction. The leucocyte migration inhibition values were significantly higher than control values in another 10 patients with late complications of previous infarction and in those patients with acute myocardial infarction who were less than 40 years of age, who had extensive anterior infarction, or who had a past history ofangina pectoris. The leucocyte migration inhibition values were negligible in all the 12 patients with stable angina pectoris, but were high in 2 of the 8 with unstable angina and in 3 of the 4 with the intermediate coronary syndrome. The leucocyte migration inhibition values were much higher inpatients with complications, which may be the result of cardiac damage by a cell-mediated immune response.

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“…13, 14, 19, 26). Heine et al [13] reported that 46% of pa-ticnts with acute myocardial infarction showed a fourfold or more increase in anti cardiac antibody titers during the 1st month, while 42% of patients with acute coronary insufficiency showed a similar rise. Wartenberg and Brostofj [27] reported an increased production of leukocyte migration inhibition factor in patients with myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

“…Many in vestigators have reported the presence of anticardiac antibodies in patients with my ocardial infarction ranging from 1 to 86%> [5,8,9,13,14,19,20,24], T lymphocytes are identified by sponta neous rosette formation with sheep crythrocytes (SRBC) [ 171 and B lymphocytes are characterized by the presence of surface im munoglobulins [21] and receptors for IgG Fc [3], complement components [23] and mouse erythrocytes (MRBC) [10][11][12]. T lymphocytes are important in regulation of antibody response of B cells to certain anti gens [7], The purpose of this investigation was to study the proportions of T lympho cytes and anticardiac antibodies in patients with a variety of ischemic heart diseases.…”

Section: Introductionmentioning

confidence: 99%

T Lymphocytes and Anticardiac Antibodies in Patients with Ischemic Heart Diseases

Agrawal¹,

Gupta²,

Chaturvedi³

et al. 1978

Int Arch Allergy Immunol

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85 patients with a variety of ischemic heart diseases were examined for the proportion of T cells and the presence of anticardiac antibodies. Patients with acute myocardial infarction during the 2nd and 3rd week of initial acute episode had a higher proportion of T lymphocytes and a higher proportion of patients developed anticardiac antibody. Similar was the case with patients with angina. The extent of infarction and accompanying complications did not change the immune parameters studied. The relationship of anticardiac antibodies and T lymphocytes in context of ischemic heart diseases is discussed.

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Antibodies to cardiac tissue in acute ischemic heart disease

Cited by 36 publications

References 11 publications

Positive indium-111 leukocyte imaging in post myocardial infarction syndrome

Positive indium-111 leukocyte imaging in post myocardial infarction syndrome

Leucocyte migration inhibition test in cases of ischaemic heart disease.

T Lymphocytes and Anticardiac Antibodies in Patients with Ischemic Heart Diseases

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