Antibodies to different strains of hantavirus in end-stage renal disease in USA and Japan

Peter, JamesB.; Patnaik, Madhumita; Gött, Peter; Weins, Brigitte; Souw, PeterT.S.

doi:10.1016/s0140-6736(94)90976-8

Cited by 8 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also in our study, none of the patients reported any hospitalization due to Hantavirus-associated symptoms, suggesting a subclinical infection. Whether a subclinical infection could result in renal scarring or a susceptibility to renal damage is to our knowledge not known; however, studies have reported a higher prevalence of antibodies against Hantavirus in other CKD populations compared to controls [ 47 , 48 ]. We cannot rule out any prior leptospirosis infection in the present study since IgG levels were not measured.…”

Section: Discussionmentioning

confidence: 99%

Morphological and clinical findings in Sri Lankan patients with chronic kidney disease of unknown cause (CKDu): Similarities and differences with Mesoamerican Nephropathy

et al. 2018

View full text Add to dashboard Cite

In Sri Lanka, an endemic of chronic kidney disease of unknown origin (CKDu) is affecting rural communities. The endemic has similarities with Mesoamerican Nephropathy (MeN) in Central America, however it has not yet been clarified if the endemics are related diagnostic entities. We designed this study of kidney biopsies from patients with CKDu in Sri Lanka to compare with MeN morphology. Eleven patients with CKDu were recruited at the General Hospital, Polonnaruwa, using similar inclusion and exclusion criteria as our previous MeN studies. Inclusion criteria were 20–65 years of age and plasma creatinine 100–220 μmol/L. Exclusion criteria were diabetes mellitus, uncontrolled hypertension and albuminuria >1g/24h. Kidney biopsies, blood and urine samples were collected, and participants answered a questionnaire. Included participants were between 27–61 years of age and had a mean eGFR of 38±14 ml/min/1.73m2. Main findings in the biopsies were chronic glomerular and tubulointerstitial damage with glomerulosclerosis (8–75%), glomerular hypertrophy and mild to moderate tubulointerstitial changes. The morphology was more heterogeneous and interstitial inflammation and vascular changes were more common compared to our previous studies of MeN. In two patients the biopsies showed morphological signs of acute pyelonephritis but urine cultures were negative. Electrolyte disturbances with low levels of serum sodium, potassium, and/or magnesium were common. In the urine, only four patients displayed albuminuria, but many patients exhibited elevated α-1-microglobulin and magnesium levels. This is the first study reporting detailed biochemical and clinical data together with renal morphology, including electron microscopy, from Sri Lankan patients with CKDu. Our data show that there are many similarities in the biochemical and morphological profile of the CKDu endemics in Central America and Sri Lanka, supporting a common etiology. However, there are differences, such as a more mixed morphology, more interstitial inflammation and vascular changes in Sri Lankan patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Morphological and clinical findings in Sri Lankan patients with chronic kidney disease of unknown cause (CKDu): Similarities and differences with Mesoamerican Nephropathy

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Liver impairment and damage occurs more frequently but the mortality is low (c. 1 There is an association between hantavirus seropositivity and patients who present with proteinuria and end-stage renal 25 In May 1993, the first cases of HPS were described in New Mexico. 26 The illness presents with a sudden onset of fever, headache, myalgia and cough.…”

Section: H a Ntavirus I Nfect Ionmentioning

confidence: 99%