Antibodies to dna in patients with rheumatoid arthritis and juvenile rheumatoid arthritis

Abstract

Antibodies to double‐stranded DNA (DSDNA) were found in 18 patients with RA, in 5 patients with JRA, and in 5 patients with undiagnosed connective tissue disease. Five patients had clinical features consistent with both RA and SLE, 11 with only RA, and 5 with only JRA. Based on these observations, the presence of serum anti‐DSDNA antibodies should not be used as a sole criterion in the diagnosis of SLE.

Characteristics of an Antigen Reactivity in Synovial Fluids and Its Association with Rheumatoid Arthritis

“…In these studies as well, although 90% of RA fluids are "positive" by IEP analyses, 38% of non-RA sam-ples were also positive. As discussed by Bell et al (19), such results may be expected because the connective tissue diseases are characterized by a spectrum of common features, some of which predominate for a particular disease.…”

Reassessment of the clinical significance of native dna antibodies in systemic lupus erythematosus

“…Currently, these two tests are widely used to monitor the clinical course of patients with lupus nephritis. However, recent reports of nDNA antibodies in normal controls (8) and in patients with diseases other than SLE (9)(10)(11)(12)(13)(14) have raised questions about the specificity and clinical usefulness of nDNA antibody determinations. These findings have arisen since the radioimmunoassay (RIA) has come into wide use as the major assay for nDNA antibodies.…”

Reaction of systemic lupus erythematosus antinative DNA antibodies with native DNA fragments from 20 to 1,200 base pairs.

“…a close association between the presence of these antibodies and SLE and, in particular, with periods of disease activity (1)(2)(3)(4). The use of assays that measure primary binding of antigen has revealed some anti-DNA activity in non-SLE sera (5,6), but with careful characterization of the test antigen, the assay conditions, and quantitation, high DNA binding activity and SLE remain closely and nearly uniquely correlated (7).…”