1990
DOI: 10.1002/art.1780331122
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Antibodies to human herpesvirus‐6 in Sjögren's syndrome

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Cited by 20 publications
(5 citation statements)
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“…The lower prevalence found in our study reflect improvements made to the specificity of the IFA by inclusion of a saturation step [Ranger-Rogez et al, 19941 and use of F(ab'), fragments. Previous evaluations of the distribution of HHV-6 antibodies in PSS patients have given varied results [Biberfeld et al, 1988;Baboonian et al, 1990;Fillet et al, 19921 and are discussed elsewhere [Ranger-Rogez et al, 19941. When mean titers of antibody were measured in our study groups, PSS patients were found to have raised levels with respect to controls, thus probably reflecting polyclonal B-cell stimulation known to occur in this disease.…”
Section: Discussionmentioning
confidence: 98%
“…The lower prevalence found in our study reflect improvements made to the specificity of the IFA by inclusion of a saturation step [Ranger-Rogez et al, 19941 and use of F(ab'), fragments. Previous evaluations of the distribution of HHV-6 antibodies in PSS patients have given varied results [Biberfeld et al, 1988;Baboonian et al, 1990;Fillet et al, 19921 and are discussed elsewhere [Ranger-Rogez et al, 19941. When mean titers of antibody were measured in our study groups, PSS patients were found to have raised levels with respect to controls, thus probably reflecting polyclonal B-cell stimulation known to occur in this disease.…”
Section: Discussionmentioning
confidence: 98%
“…In another study, 49 patients with primary Sjögren's syndrome and 50 age-and sex-matched normal controls had similar rates of HHV-6 seroprevalence or prevalence of HHV-6 DNA detected by PCR in PBMCs or salivary gland biopsy specimens (424). HHV-6 antibody titers in 25 women with rheumatoid arthritis were either lower or slightly higher than in an equal number of age-and sexmatched healthy controls, when measured by IFA or enzymelinked immunosorbent assay, respectively (38). HHV-6 has been isolated from peripheral blood lymphocytes of several patients with various collagen vascular diseases, most often from patients with systemic lupus erythematosus (295).…”
Section: Collagen Vascular Diseasesmentioning
confidence: 89%
“…The relevant studies are summarized here. A cohort of 25 women with primary Sjögren's syndrome had no significant differences in HHV-6 seroprevalence or antibody titers compared with a group of 25 age-matched healthy women (38). In another study, 49 patients with primary Sjögren's syndrome and 50 age-and sex-matched normal controls had similar rates of HHV-6 seroprevalence or prevalence of HHV-6 DNA detected by PCR in PBMCs or salivary gland biopsy specimens (424).…”
Section: Collagen Vascular Diseasesmentioning
confidence: 94%
“…The epidemiology and clinical consequences of HHV-6A infections are not as fully defined; however, primary HHV-6A infection has been reported in one case of exanthem subitum (25). HHV-6 infections have also been associated with encephalitis (4), hepatitis (3), multiple sclerosis, chronic fatigue syndrome, and some lymphomas, although a formal causal association has not been proven (5,7,31,48). In individuals who are immunosuppressed by drugs, such as transplant patients, or individuals infected with human immunodeficiency virus, HHV-6 is emerging as an important pathogen.…”
mentioning
confidence: 99%