2019
DOI: 10.1177/0961203319828521
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Antibodies to M-type phospholipase A2 receptor (PLA2R) in membranous lupus nephritis

Abstract: Background Antibodies to M-type phospholipase A2 receptor (a-PLA2R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was to assess the prevalence of a-PLA2R antibodies in a large cohort of patients with lupus nephritis. Methods a-PLA2R antibodies were measured by ELISA in serum from patients with systemic lupus erythematosus ( n = 190), of whom 37 had a biopsy-proven MLN. Positive s… Show more

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Cited by 33 publications
(25 citation statements)
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“…described 7 PLA2R-positive cases among 37 lupus MN cases studied (19%). 29 Whether PLA2R positivity in secondary MN is due to a coincidental presence of primary MN in patients with an unrelated systemic disease is not clearly known. IgG subclass staining might help resolve the correct diagnosis in these cases, predominant IgG4 pattern favoring coexistent disease with PLA2R-related PMN.…”
Section: Discussionmentioning
confidence: 99%
“…described 7 PLA2R-positive cases among 37 lupus MN cases studied (19%). 29 Whether PLA2R positivity in secondary MN is due to a coincidental presence of primary MN in patients with an unrelated systemic disease is not clearly known. IgG subclass staining might help resolve the correct diagnosis in these cases, predominant IgG4 pattern favoring coexistent disease with PLA2R-related PMN.…”
Section: Discussionmentioning
confidence: 99%
“…Of note some previous studies reported a rare presence of anti-PLA2R Ab in SMN patients. In fact, Garcia-Vives et al [15], Radice et al [16], Qin et al [17] and Hofstra et al [18] noted that SLE patients with membranous lupus nephritis (MLN) had anti-PLA2R Ab at frequencies of 5.3%, 5.4%, 5% and 5%, respectively. This rare positivity of anti-PLA2R Ab during MLN could be due to a bystander activation of self-reactive T and B cells.…”
Section: Plos Onementioning
confidence: 99%
“…9 In a study by Garcia-Vives et al., anti-PLA2R antibody positivity was observed in 5.3% of all SLE patients and 18.9% of patients with MLN diagnosis. 10…”
Section: Discussionmentioning
confidence: 99%