Antibodies to Merkel Cell Polyomavirus Correlate to Presence of Viral DNA in the Skin

Faust, Helena; Pastrana, Diana V.; Buck, Christopher B.; Dillner, Joakim; Ekström, Johanna

doi:10.1093/infdis/jiq173

Cited by 43 publications

(48 citation statements)

References 15 publications

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“…The seroprevalence for MCV among children was around 30 %, which is also in agreement with other studies (23). Seroprevalences of JCV and MCV in the adult Slovenian women were also similar (around 65 %) to other studies of European adults (24).…”

Section: Discussionsupporting

confidence: 91%

Serum antibodies to human papillomavirus (HPV) pseudovirions correlate with natural infection for 13 genital HPV types

Faust

Jelen

Poljak

et al. 2013

Journal of Clinical Virology

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Serum antibodies to human papillomavirus (HPV) pseudovirions correlate with natural infection for 13 genital HPV types.Faust, Helena; Jelen, Mateja M; Poljak, Mario; Klavs, Irena; Učakar, Veronika; Dillner, Joakim General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal 1 SERUM ANTIBODIES TO HUMAN PAPILLOMAVIRUS (HPV) PSEUDOVIRIONS CORRELATE WITH NATURAL INFECTION FOR 13 GENITAL HPV TYPES

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Section: Discussionsupporting

confidence: 91%

Serum antibodies to human papillomavirus (HPV) pseudovirions correlate with natural infection for 13 genital HPV types

Faust

Jelen

Poljak

et al. 2013

Journal of Clinical Virology

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“…A correlation between MCPyV loads and antibody titers has been reported (22,23), suggesting that life-long persistence of MCPyV infection is correlated with higher antibody levels. The increase in MCPyV antibody levels with age may thus reflect the fact that subjects with high antibody titers had active viral replication associated with VP1 production, a state more frequently observed in older subjects due to waning immunity.…”

Section: Discussionmentioning

confidence: 94%

Age-Specific Seroprevalences of Merkel Cell Polyomavirus, Human Polyomaviruses 6, 7, and 9, and Trichodysplasia Spinulosa-Associated Polyomavirus

Nicol¹,

Robinot²,

Carpentier³

et al. 2013

Clin. Vaccine Immunol.

136

165

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. The presence of specific antibodies against MCPyV, HPyV6, HPyV7, HPyV9, and TSPyV in 828 Italian subjects aged 1 to 100 years was investigated by virus-like particle-based enzyme-linked immunosorbent assays (ELISAs). The findings indicate that all of these new polyomaviruses circulate widely in humans, with seroprevalences in adulthood ranging from 39.4% for HPyV9 to 87.1% for MCPyV, and that primary exposure is most intense in childhood, with the exception of HPyV7 and HPyV9, for which the seroprevalence increased throughout life. The proportion of subjects with high antibody titers was found to increase with age for MCPyV and to decrease with age for TSPyV.

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“…Seroprevalence of 50-95% is reported in adults (7,(12)(13)(14)(25)(26)(27)(28)(29). The age-specific seroprevalence of MCPyV (Fig.…”

Section: Serologymentioning

confidence: 96%

“…MCPyV DNA has been detected at varying levels of frequency (0-100%) in skin samples, and in anal and penile swabs (1,9,20,21,26,(32)(33)(34)(35)(36)(37)(38). The MCPyV viral load on the skin surface varies from less than 1 copy per 1000 cells to 1000 copies per cell (9,26,30,(39)(40)(41).…”

Section: Detection Of the Viral Genomementioning

confidence: 99%

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Human Merkel cell polyomavirus: virological background and clinical implications

Coursaget

Samimi

Nicol

et al. 2013

APMIS

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The Merkel cell polyomavirus (MCPyV), identified in humans in 2008, is associated with a relatively rare but aggressive neuroendocrine skin cancer, the Merkel cell carcinoma (MCC). MCC incidence is increasing due to the advancing age of the population, the increase in damaging sun exposure and in the number of immunocompromised individuals. MCPyV must be considered as the etiological agent of MCC and thus is the first example of a human oncogenic polyomavirus. MCPyV infection is common, and seroprevalence studies indicate that widespread exposure begins early in life. The majority of adults have anti-MCPyV antibodies and there is a growing body of evidence that healthy human skin harbors resident or transient MCPyV suggesting that MCPyV infection persists throughout life. However, the mode of transmission, the host cells, and the latency characteristics of this virus remain to be elucidated. In addition, it is still not clear whether MCPyV is associated with diseases or lesions other than Merkel cell carcinoma. The etiologic role of MCPyV in MCC opens up opportunities to improve the understanding of this cancer and to potentially improve its treatment.

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Antibodies to Merkel Cell Polyomavirus Correlate to Presence of Viral DNA in the Skin

Cited by 43 publications

References 15 publications

Serum antibodies to human papillomavirus (HPV) pseudovirions correlate with natural infection for 13 genital HPV types

Serum antibodies to human papillomavirus (HPV) pseudovirions correlate with natural infection for 13 genital HPV types

Age-Specific Seroprevalences of Merkel Cell Polyomavirus, Human Polyomaviruses 6, 7, and 9, and Trichodysplasia Spinulosa-Associated Polyomavirus

Human Merkel cell polyomavirus: virological background and clinical implications

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