Antibodies to mutated citrullinated vimentin and anti-cyclic citrullinated peptide antibodies in inflammatory bowel disease and related arthritis

Al-Jarallah, Khaled; Shehab, Diaa; Al‐Attiyah, Rajaa; Alazmi, Waleed; Al-Fadli, Ahmad; Haider, Mohammed Z.; Panaccione, Remo; Ghosh, Subrata

doi:10.1002/ibd.21937

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…Arthralgia was not clearly defined; therefore, it could have been that enthesitis and fibromyalgia were also in part responsible for these large numbers. Notwithstanding, our study confirms the results of other studies that found no association between articular manifestations and ACPA in IBD patients [21,22,40].…”

Section: Discussionsupporting

confidence: 92%

“…In the current study, we measured the serological levels of ACPA (of the immunoglobulin A (IgA) and immunoglobulin G (IgG) type) and RF (IgM and IgA) in a cross-sectional group of IBD patients. It is reported in the literature that IgA ACPA [18,19] and IgG ACPA [20][21][22] have a low prevalence in IBD patients. None of these studies assessed the presence of low ACPA levels below the diagnostic cut-off, however.…”

Section: Introductionmentioning

confidence: 99%

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Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease

Janssen

Hop

Vissink

et al. 2020

IJERPH

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Systemic presence of arthritis autoantibodies (AAb) is specific for rheumatoid arthritis (RA). AAb initiation might be triggered by chronic mucosal inflammation, such as in inflammatory bowel disease (IBD). We assessed the prevalence of anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) in ulcerative colitis (UC) and Crohn’s disease (CD) patients, with regard to the prevalence of joint complaints in AAb+ versus AAb− IBD patients. RA patients and healthy subjects (HC) served as controls. Serum was collected from 226 UC, 165 CD and 86 RA patients, and 36 HCs. One-hundred-and-ten UC (48.7%) and 76 CD (46.1%) patients were seropositive for at least one autoantibody, compared to 4 (13.9%) HCs and 81 (94.2%) RA patients. Eighty-three (37%) UC and 52 (32%) CD patients were seropositive for the anti-cyclic citrullinated protein antibody (anti-CCP2) of the immunoglobulin A type (IgA anti-CCP2), compared to 1 (2.8%) HC and 64 (74%) RA patients. RF of the immunoglobulin G type (IgG RF) and IgA RF seropositivity in UC and CD patients was comparable to HCs and low compared to RA patients. Arthralgia was reported by 34 (18.7%) UC and 50 (33.1%) CD patients, but presence of arthralgia was not increased in AAb+ patients. AAbs are frequently present in IBD patients, supporting the hypothesis that inflammation of intestinal mucosa induces low systemic levels of ACPA.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease

Janssen

Hop

Vissink

et al. 2020

IJERPH

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“…and ). Then, 378 full texts were assessed for eligibility and, finally, 78 papers were included in the qualitative and quantitative analysis: 67 for the analysis of the prevalence of co‐existing IBD‐SpA (Tables and ) and only 11 for the diagnostic accuracy of red flags .…”

Section: Resultsmentioning

confidence: 99%

Red flags for appropriate referral to the gastroenterologist and the rheumatologist of patients with inflammatory bowel disease and spondyloarthritis

Felice

Leccese

Scudeller

et al. 2019

Clinical and Experimental Immunology

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Collaboration between gastroenterologists and rheumatologists is recommended for the correct management of patients with associated spondyloarthritis (SpA) and inflammatory bowel disease (IBD). We aimed to establish the appropriateness of several red flags for a prompt specialist referral. A systematic review of the literature was performed using the GRADE method to describe the prevalence of co-existing IBD-SpA and the diagnostic accuracy of red flags proposed by a steering committee. Then, a consensus among expert gastroenterologists and rheumatologists (10 in the steering committee and 13 in the expert panel) was obtained using the RAND method to confirm the appropriateness of each red flag as 'major' (one sufficient for patient referral) or 'minor' (at least three needed for patient referral) criteria for specialist referral. The review of the literature confirmed the high prevalence of co-existing IBD-SpA. Positive and negative predictive values of red flags were not calculated, given the lack of available data. A consensus among gastroenterology and rheumatology specialists was used to confirm the appropriateness of each red flag. Major criteria to refer patients with SpA to the gastroenterologist included: rectal bleeding, chronic abdominal pain, perianal fistula or abscess, chronic diarrhoea and nocturnal symptoms. Major criteria to refer patients with IBD to the rheumatologist included: chronic low back pain, dactylitis, enthesitis and pain/swelling of peripheral joints. Several major and minor red flags have been identified for the diagnosis of co-existing IBD-SpA. The use of red flags in routine clinical practice may avoid diagnostic delay and reduce clinic overload.

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“…PA has proven to be more common, affecting 5%-20% of patients with IBD [ 19 ]. According to a study conducted in Kuwait on a sample population of 125, from which 81 people were diagnosed with IBD, it was concluded that 39.8% (29/81) patients were affected with PA while only 9.9% (8/81) patients were affected with AA [ 21 ]. Management of arthropathies has been based on controlling the clinical activity of the disease.…”

Section: Reviewmentioning

confidence: 99%

Extra-Intestinal Manifestations of Inflammatory Bowel Disease

Sange¹,

Srinivas²,

Sarnaik³

et al. 2021

Cureus

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Inflammatory bowel disease (IBD) is associated with extra-intestinal manifestations (EIMs) that tend to parallel intestinal activity and have a debilitating effect on the quality of life. EIMs primarily affect the joints, skin, and eyes with less frequent involvement of the liver, kidney, and pancreas. This article reviews the prevalence of musculoskeletal, dermatological, ocular, and other manifestations in IBD and their coalition with underlying intestinal inflammation. EIMs occurring independently of intestinal activity are managed by targeted therapies, categorical regimens, and specific treatments. On the other hand, EIMs paralleling the bowel activity are carefully monitored while the IBD is brought under control. Since the etiology of the disease is responsible for the development of the EIMs, the research scrutinizes the identified pathogenic mechanisms that tend to involve genetic susceptibility, aberrant self-recognition, and autoantibodies directed against organ-specific antigens shared by intestinal and extra-intestinal organs. This article also provides an overview of the epidemiology, clinical features, diagnostic modalities, and management of the EIMs associated with IBD.

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Antibodies to mutated citrullinated vimentin and anti-cyclic citrullinated peptide antibodies in inflammatory bowel disease and related arthritis

Abstract: Autoantibodies to citrullinated proteins were low in IBD-related arthritis. These findings suggest that these antibodies are not useful biomarkers in IBD to predict who may develop IBD-related arthropathy.

Cited by 7 publications

References 23 publications

Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease

Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease

Red flags for appropriate referral to the gastroenterologist and the rheumatologist of patients with inflammatory bowel disease and spondyloarthritis

Extra-Intestinal Manifestations of Inflammatory Bowel Disease

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