Antibodies to native and denatured DNA in the serum of patients with schizophrenia depending on the clinical features of the disease

Smirnova, L.; Ermakov, Evgeny A.; Boyko, Andriy; Бохан, Н. А.; Semke, A.; Ivanova, Svetlana A.

doi:10.17116/jnevro20161164147-51

Cited by 1 publication

(1 citation statement)

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“…This can lead not only to inflammatory responses after recognition of cfDNA and histones by Toll-like receptors [ 5 , 11 ], but also to their presentation as antigens and the generation of autoantibodies. This assumption is supported by the fact that there is an increase in anti-DNA antibody titers in schizophrenia [ 16 , 17 , 18 , 19 , 51 ]. Anti-DNA antibodies are also known to cross-bind to the nucleosome and histone proteins [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Natural Catalytic IgGs Hydrolyzing Histones in Schizophrenia: Are They the Link between Humoral Immunity and Inflammation?

Ermakov

Parshukova

Nevinsky

et al. 2020

IJMS

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Schizophrenia is known to be accompanied not only with an imbalance in the neurotransmitter systems but also with immune system dysregulation and chronic low-grade inflammation. Extracellular histones and nucleosomes as damage-associated molecular patterns (DAMPs) trigger systemic inflammatory and toxic reactions by activating Toll-like receptors. In this work, we obtained the first evidence that polyclonal IgGs of patients with schizophrenia effectively hydrolyze five histones (H1, H2a, H2b, H3, and H4). Several strict criteria were used to demonstrate that histone-hydrolyzing activity is a property of the analyzed IgGs. The IgGs histone-hydrolyzing activity level, depending on the type of histone (H1–H4), was statistically significantly 6.1–20.2 times higher than that of conditionally healthy donors. The investigated biochemical properties (pH and metal ion dependences, kinetic characteristics) of these natural catalytic IgGs differed markedly from canonical proteases. It was previously established that the generation of natural catalytic antibodies is an early and clear sign of impaired humoral immunity. One cannot, however, exclude that histone-hydrolyzing antibodies may play a positive role in schizophrenia pathogenesis because histone removal from circulation or the inflamed area minimizes the inflammatory responses. Thus, it can be assumed that histone-hydrolyzing antibodies are a link between humoral immunity and inflammatory responses in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Natural Catalytic IgGs Hydrolyzing Histones in Schizophrenia: Are They the Link between Humoral Immunity and Inflammation?

Ermakov

Parshukova

Nevinsky

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

Antibodies to native and denatured DNA in the serum of patients with schizophrenia depending on the clinical features of the disease

Abstract: The results suggest that anti-DNAantibodies may not play a major role in the pathogenesis of schizophrenia.

Cited by 1 publication

References 13 publications

Natural Catalytic IgGs Hydrolyzing Histones in Schizophrenia: Are They the Link between Humoral Immunity and Inflammation?

Natural Catalytic IgGs Hydrolyzing Histones in Schizophrenia: Are They the Link between Humoral Immunity and Inflammation?

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