Antibodies to opacity proteins (Opa) correlate with a reduced risk of gonococcal salpingitis.

Plummer, Francis A.; Chubb, Helen; Simonsen, J. Neil; Bosire, M; Slaney, L; Nagelkerke, Nico; Maclean, I. L.; Ndinya-Achola, J. O.; Waiyaki, Peter; Brunham, R. C.

doi:10.1172/jci117159

Cited by 49 publications

(33 citation statements)

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“…They also reported that urethral infection by gonococci induced anti-LOS IgG in six of nine patients who had no detectable Ab in their preinfection sera. The importance of serum antibodies in the course of gonococcal infection has been reported by Plummer et al, who have shown that antibodies against selected gonococcal surface antigens can either increase or decrease the susceptibility to disease (31,32). Furthermore, the specificity of serum and local antibodies of female patients have been analyzed (14,20), and IgG and IgA against pili, LOS, porin protein I, and opacity proteins have been detected in both serum and vaginal fluids.…”

Section: Vol 78 2010 Los Contains Epitopes Recognized By Human Antimentioning

confidence: 90%

The Oligosaccharide of Gonococcal Lipooligosaccharide Contains Several Epitopes That Are Recognized by Human Antibodies

et al. 2010

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Section: Vol 78 2010 Los Contains Epitopes Recognized By Human Antimentioning

confidence: 90%

The Oligosaccharide of Gonococcal Lipooligosaccharide Contains Several Epitopes That Are Recognized by Human Antibodies

et al. 2010

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“…The hallmark of humoral immune response against N. gonorrhoeae is the extremely low levels of antigonococcal antibodies found in serum and secretions of the human (male and female) during infection (19,20). Antibodies are directed against several major membrane molecules, such as the pilusand opacity-associated outer membrane proteins (Pil and Opa, respectively), the porin protein (Por), and the lipooligosaccharide (5,19,20,38,39,55). Although some of these have bactericidal activity, they are not protective and seem to be blocked by outer membrane protein 3 (RmP)-specific immunoglobulin Gs (IgGs) (38).…”

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confidence: 99%

Regulatory T Cells Are Locally Induced during Intravaginal Infection of Mice withNeisseria gonorrhoeae

et al. 2008

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Neisseria gonorrhoeae is a gram-negative diplococcus that in human beings produces gonorrhea. Much clinical evidence has led to the conclusion that gonococcus has important mechanisms to evade host immune functions; however, these mechanisms are only now beginning to be elucidated. In this study, we determined that the BALB/c mouse is a good animal model to study gonococcus infection and examined the immune response against the bacteria. We determined that after intravaginal inoculation of mice with Neisseria gonorrhoeae, the bacteria reached and invaded the upper female reproductive tissues and elicited a T-cellspecific immune response associated with a very weak humoral response, altogether resembling gonococcus infection and disease in women. Remarkably, in the draining lymph nodes of the genital tracts of infected mice, we found an increase of regulatory T lymphocytes, namely, transforming growth factor ␤1-positive CD4 ؉ T cells and CD4؉ CD25 ؉ Foxp3 ؉ T cells. Altogether, results indicate that N. gonorrhoeae induces regulatory T cells, which might be related to the local survival of the pathogen and the establishment of a chronic asymptomatic infection.

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“…The vaccine was contaminated with other outer membrane components; at least one that was present (Rmp antigen) is known to subvert the killing function of the Por-specific immune response (14). In the Por vaccine study, and in several additional contemporaneously performed natural history studies in women, modeling of the immune status of subjects exposed to N. gonorrhoeae has suggested that immunity against several outer membrane components together may predict protection from infection (15,16) or, alternatively, may enhance the likelihood of infection (17), depending on the relative contributions of specific immune responses. Therefore, a successful vaccine may have to be multivariate, targeting conserved epitopes while avoiding subversive immunogens.…”

Section: Session 3: Human Studiesmentioning

confidence: 99%

Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop “Gonorrhea Vaccines: the Way Forward”

Wetzler

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Gray-Owen

et al. 2016

Clin Vaccine Immunol

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There is an urgent need for the development of an antigonococcal vaccine due to the increasing drug resistance found in this pathogen. The U.S. Centers for Disease Control (CDC) have identified multidrug-resistant gonococci (GC) as among 3 "urgent" hazard-level threats to the U.S. population. In light of this, on 29 to 30 June 2015, the National Institute for Allergy and Infectious Diseases (NIAID) sponsored a workshop entitled "Gonorrhea Vaccines: the Way Forward." The goal of the workshop was to gather leaders in the field to discuss several key questions on the current status of gonorrhea vaccine research and the path forward to a licensed gonorrhea vaccine. Representatives from academia, industry, U.S. Government agencies, and a state health department were in attendance. This review summarizes each of the 4 scientific sessions and a series of 4 breakout sessions that occurred during the one and a half days of the workshop. Topics raised as high priority for future development included (i) reinvigoration of basic research to understand gonococcal infection and immunity to allow intervention in processes essential for infection; (ii) clinical infection studies to establish parallels and distinctions between in vitro and animal infection models versus natural human genital and pharyngeal infection and to inform in silico modeling of vaccine impact; and (iii) development of an integrated pipeline for preclinical and early clinical evaluation and direct comparisons of potential vaccine antigens and adjuvants and routes of delivery.

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Antibodies to opacity proteins (Opa) correlate with a reduced risk of gonococcal salpingitis.

Abstract: Acute salpingitis complicating cervical gonococcal infection is a significant cause of infertility. Relatively little data are available concerning the pathophysiologic mechanisms of this disease. Clin. Invest. 1994. 93:1748-1755.

Cited by 49 publications

References 44 publications

The Oligosaccharide of Gonococcal Lipooligosaccharide Contains Several Epitopes That Are Recognized by Human Antibodies

The Oligosaccharide of Gonococcal Lipooligosaccharide Contains Several Epitopes That Are Recognized by Human Antibodies

Regulatory T Cells Are Locally Induced during Intravaginal Infection of Mice withNeisseria gonorrhoeae

Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop “Gonorrhea Vaccines: the Way Forward”

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