Antibodies to soluble liver antigen in patients with various liver diseases: A multicentre study

Efe, Cumali; Özaslan, Ersan; Wåhlin, Staffan; Pürnak, Tuğrul; Muratori, Luigi; Quarneti, Chiara; Yüksel, Osman

doi:10.1111/liv.12022

Cited by 38 publications

(48 citation statements)

References 44 publications

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“…Anti-SLA was described in patients running a severe clinical course, having worse histology, needing a longer period to achieve remission, relapsing and requiring liver transplantation more frequently [9] . These clinical correlations, obtained with an extremely sensitive immunoassay able to identify antibodies directed to conformational epitopes, were partially replicated in a large series of patients [23] , but not in other studies [24,25] , and such a difference might be due to the different methods employed for anti-SLA detection.…”

Section: Autoantibodies Of Diagnostic Relevancementioning

confidence: 83%

Autoantibodies in Autoimmune Hepatitis

Muratori

Deleonardi²,

Lalanne

et al. 2015

Dig Dis

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Background: The detection of diagnostic autoantibodies such as antinuclear antibodies (ANA), anti-smooth muscle antibodies (SMA), anti-liver/kidney microsomal type 1 (anti-LKM1), anti-liver cytosol type 1 (anti-LC1) and anti-soluble liver antigen (anti-SLA) is historically associated with the diagnosis of autoimmune hepatitis. Key Messages: When autoimmune hepatitis is suspected, the detection of one or any combination of diagnostic autoantibodies, by indirect immunofluorescence or immuno-enzymatic techniques with recombinant antigens, is a pivotal step to reach a diagnostic score of probable or definite autoimmune hepatitis. Conclusions: Diagnostic autoantibodies (ANA, SMA, anti-LKM1, anti-LC1, anti-SLA) are a cornerstone in the diagnosis of autoimmune hepatitis. Other ancillary autoantibodies, associated with peculiar clinical correlations, appear to be assay-dependent and institution-specific, and validation studies are needed.

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Section: Autoantibodies Of Diagnostic Relevancementioning

confidence: 83%

Autoantibodies in Autoimmune Hepatitis

Muratori

Deleonardi²,

Lalanne

et al. 2015

Dig Dis

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“…Of these, 15 (51.7%) studies were in English [45]–[59] and 14 (48.3%) were in Chinese [60]–[73]. Eighteen studies on 968 patients investigated the diagnostic accuracy of ANA [45]–[47], [50], [52], [54], [59]–[62], [64]–[68], [70], [71], [73], 22 studies on 1,193 patients reported on the diagnostic accuracy of SMA [46], [47], [50], [52]–[55], [57]–[59], [60]–[65], [67]–[71], [73], and 16 studies on 850 patients focused on the diagnostic accuracy of anti-SLA/LP [46]–[52], [56], [60], [63], [65], [68]–[70], [72], [73].…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis: Diagnostic Accuracy of Antinuclear Antibodies, Smooth Muscle Antibodies and Antibodies to a Soluble Liver Antigen/Liver Pancreas in Autoimmune Hepatitis

Zhang

Zhao²,

Chen

et al. 2014

PLoS ONE

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BackgroundAntinuclear antibodies (ANA), smooth muscle antibodies (SMA) and antibodies to a soluble liver antigen/liver pancreas (anti-SLA/LP) are useful markers that can help clinicians to diagnose and classify autoimmune hepatitis (AIH).ObjectivesTo determine whether ANA, SMA and anti-SLA/LP help to accurately diagnose patients with AIH.Search strategyThe PubMed, CNKI, WANFANG, and SinoMed databases were accessed to retrieve studies published in English and Chinese. Studies published up to October 2013 were reviewed.Selection criteriaStudies on the diagnostic value of ANA, SMA or anti-SLA/LP in the diagnosis of known or suspected AIH were included.Data collection and analysisTwo authors evaluated studies independently and rated their methodological quality using quality assessment of diagnostic accuracy studies (QUADAS) tools; relevant data were abstracted. The random-effects method was used to summarize sensitivities, specificities, positive and negative likelihood ratios, and diagnostic odds ratios (DORs) from all 29 studies.ResultsThe pooled sensitivity, specificity, positive and negative likelihood ratios, and DOR for ANA were 0.650 (95% confidence interval [CI], 0.619 to 0.680), 0.751 (95%CI, 0.737 to 0.764), 3.030 (95%CI, 2.349 to 3.910), 0.464 (95%CI, 0.356 to 0.604), and 7.380 (95%CI, 4.344 to 12.539), respectively. For SMA, the values were 0.593 (95%CI, 0.564 to 0.621), 0.926 (95%CI, 0.917 to 0.934), 11.740 (95%CI, 7.379 to 18.678), 0.449 (95%CI, 0.367 to 0.549), and 31.553 (95%CI, 17.147 to 58.060), respectively. Finally, for anti-SLA/LP, the values were 0.194 (95%CI, 0.168 to 0.222), 0.989 (95%CI, 0.985 to 0.993), 11.089 (95%CI, 7.601 to 16.177), 0.839 (95%CI, 0.777 to 0.905), and 16.867 (95%CI, 10.956 to 25.967), respectively.Authors’ conclusionsANA provided moderate sensitivity and specificity, while SMA gave moderate sensitivity and high specificity, and anti-SLA/LP exhibited low sensitivity and high specificity. All three antibodies were limited by their unsatisfactory sensitivities and lack of consistency.

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“…Lactation without pregnancy could be explained by hyperprolactinemia. Associations of AIH with primary biliary cirrhosis and primary sclerosing cholangitis have been described [2] . Association of AIH with organ specific polyglandular autoimmune disease have also been found due to defect in autoimmune regulatory gene (AIRE) but no association with microadenoma of pituitary and hyperprolactinemia have been described [1] .…”

Section: Discussionmentioning

confidence: 99%

“…Anti SLA have high specificity for AIH because 90% cases anti SLA positive patients have AIH & only 10% have primary biliary cirrhosis. Biochemical remission is achieved in 90% anti SLA positive AIH but relapse is seen in 53% patients after withdrawal of immunosuppressive drugs [2] . Anti SLA antibody positive patient are mostly DRB1*03 positive and have anti SSA (R0-52) antibody, ANA and ASMA [3] .…”

Section: Introductionmentioning

confidence: 99%