Antibodies to Tamm–Horsfall protein in endemic nephropathy

Abstract

Determination of anti-THP antibodies was not found to be useful in the early diagnosis of endemic nephropathy. The results suggest that most of the anti-THP antibodies are 'natural' and/or cross reactive. The highest values observed in the rural population could probably be explained by exposure to some ubiquitous antigen or more likely they are consequences of fever.

Tamm–Horsfall Protein is a Potent Immunomodulatory Molecule and a Disease Biomarker in the Urinary System

“…Investigations have demonstrated decreased urinary THP excretion in endemic nephropathy [ 81 , 82 ], diabetic nephropathy [ 54 , 56 , 70 ], and lupus nephritis [ 53 ]. The decreased urinary THP production is not only a useful biomarker of renal tubular damage [ 56 , 57 , 58 ] but also an indicator of decreased clearance of systemic and renal proinflammatory cytokines, and it can thus accelerate renal inflammation.…”

“…Anti-THP antibody production has been reported in patients with endemic nephropathy [ 82 ], recurrent urinary tract infections [ 83 ], obstructive uropathy and vesicoureteral reflux [ 84 ], medullary cystic disease [ 28 , 29 ], and renal allograft rejection [ 85 ]. The abnormal deposition of THP in these diseases results from extensive tubular damage with leakage of THP from its normal intracellular and intraluminal locations into the renal interstitium [ 86 ].…”

Pathophysiology of glomerular and tubulointersal kidney diseases: Proteomic approach

“…Aristolochia-e (aristolohijska kiselina 1 i 2)[50], kao i brojnih zagađivača prisutnih u životnoj okolini. Urotelijalni tumori prelaznog epitela su prijavljeni kao česta komplikacija[51][52][53][54][55][56][57][58][59][60][61][62][63].…”