Antibodies to the oral bacterium Streptococcus mutans and the development of caries in children in relation to maternal dental treatment during pregnancy

Aaltonen, A.S.; Tenovuo, Jorma; Lehtonen, Olli‐Pekka

doi:10.1016/0003-9969(88)90093-3

Cited by 13 publications

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References 28 publications

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“…In 2 studies [Rodriguez Miro et al, 1989;Twetman et al, 1994] only data of the mutans-negative subgroup of children were used for analyses. 23 fi rst or corresponding authors [Aaltonen et al, 1987[Aaltonen et al, , 1988Ansai et al, 2000;Carlsson et al, 1975;Grindefjord et al, 1995Grindefjord et al, , 1996Hirose et al, 1993;Holbrook, 1993;Holbrook et al, 1995;Li et al, 2000;Litt et al, 1995;Mattos-Graner et al, 2001;Radford et al, 2001;Raitio et al, 1995;Reisine et al, 1994;Rodriguez Miro et al, 1989;Roeters et al, 1995;Saemundsson et al, 1992;Shi et al, 2003;Twetman et al, 1994;Twetman and Petersson, 1996;Wendt et al, 1996;Seki et al, 2003b] were contacted for data on the subset of caries-free children at baseline and for data on children tested mutans streptococci-positive at baseline. Contacting the authors allowed for the inclusion of two additional publications [Litt et al, 1995;Wendt et al, 1996], while reviewing references of relevant primary articles found no additional study.…”

Section: Results Of Literature Searchmentioning

confidence: 99%

Are Mutans Streptococci Detected in Preschool Children a Reliable Predictive Factor for Dental Caries Risk? A Systematic Review

et al. 2006

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Research suggests that mutans streptococci play an important role in cariogenesis in children but the usefulness of bacterial testing in risk assessment is unknown. Our objective was to summarize the literature assessing the association of mutans streptococci and dental caries in preschool children, (Pre)Medline (1966–2003), Embase (1980–2003), the Cochrane Register of Controlled Trials (2003, issue 3), and reference lists of included studies were searched. All abstracts found by the electronic searches (n = 981) were independently scrutinized by 2 reviewers. Minimal requirements for inclusion were assessment of preschool children without caries at baseline, reporting of mutans streptococci present in saliva or plaque at baseline and assessment of caries presence after a minimum of 6 months of follow-up. Participants’ details, test methods, methodological characteristics and findings were extracted by one reviewer and cross-checked by another. Homogeneity was tested using χ² tests. Results of plaque and saliva testing were pooled separately using a fixed effects model. Methodological quality of reports was low. Out of 9 studies included, data from 3 reports on plaque test assessment alone (n = 300) and from 4 reports on saliva test assessment alone (n = 451) were available for pooled analysis. The pooled risk ratio (95% CI) was 3.85 (2.48–5.96) in studies using plaque tests and 2.11 (1.47–3.02) in those using saliva testing. Presence of mutans streptococci, both in plaque or saliva of young caries-free children, appears to be associated with a considerable increase in caries risk. Lack of adjustment for potential confounders in the original studies, however, limits the extent to which interpretations for practice can be made.

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Section: Results Of Literature Searchmentioning

confidence: 99%

Are Mutans Streptococci Detected in Preschool Children a Reliable Predictive Factor for Dental Caries Risk? A Systematic Review

et al. 2006

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“…Sixty-seven 4.5-7.9-year-old children (26 boys and 41 girls) and their mothers who had participated in our previous invesdgadons in 1983-85 (2,3,4), volunteered for further examinations in 1986. These studies were approved by the local Health Board at Karkkila and by the Ethical Committee at the Insdtute of Dentistry in the University of Helsinki.…”

Section: Imateriai and Methods Subjects And The Immunological Assaysmentioning

confidence: 99%

“…In 1985 the participants were surveyed by means of a questionnaire for dietary and environmental factors as described by Aaltonen et al (4); sotne further data were obtained similarly in 1986. Based on the answers of the mothers in 1986, an index of the consumption frequency of refined foodstuffs and sugar for mothers, and for children, was formed scoring the lowest frequency as 1 and the highest as 15.…”

Section: Background Surveysmentioning

confidence: 99%

“…In our previous study of young children, the level of IgG antibodies to S. mutans in children's sera had been dependent on maternal dental treatment during pregnancy (4) and the number of maternal salivary close-contacts during the first nursing year (2). High levels of serum IgG antibodies to S. mutans in children seem to reduce the colonizadon of S. mutans (2,42) and protect primary teeth against dental caries (3).…”

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Maternal caries incidence and salivary close‐contacts with children affect antibody levels to Streptococcus mutans in children

Aaltonen¹,

Tenovuo

Lehtonen

1990

Oral Microbiology and Immunology

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Serum and salivary immunoglobulins and antibodies reactive with Streptococcus mutans were determined in 67 5-8-year-old children. The children of mothers whose caries incidence rates exceeded the median value had significantly more serum IgG antibodies to S. mutans than those with a lower maternal caries activity (p less than 0.05). The children (n = 14) who had been exposed to frequent maternal salivary close-contacts in their first year had significantly higher (p less than 0.05) serum total specific IgG antibodies but significantly lower (p less than 0.01) high-avidity IgG antibodies to S. mutans than the other children (n = 53) with less frequent close-contacts. The maternal caries incidence rates were significantly positively associated with children's dfs/DFS-indices (r = 0.41; p less than 0.001). However, the high maternal caries incidence did not increase the risk of caries in those children whose mothers' saliva contained high amounts of lactobacilli during the first nursing year, when compared with matched children with a low maternal level of lactobacilli. This was possibly due to the fact that the former children had significantly (p less than 0.05) more anti-S. mutans IgG antibodies in their sera than the latter.

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“…The main source of infection is usually maternal saliva [Ber kowitz et ai., 1981;Berkowitz and Jones, 1985;Köhler and Bratthall, 1978;Masuda et ai., 1985] and high ma ternal salivary S. mutans levels (> 105cfu/ml) en hance its colonization [Berkowitz et al, 1981]. It has also been shown that the earlier the colonization by S. mutans, the more prone the children are to dental caries [Alaluusua and Renkonen, 1983;Köhler et al, 1988], Specific antibodies of secretory IgA isotype (in sal iva, milk or tears) and of IgG, IgM and IgA isotypes (in serum and crevicular fluid) against MS are found in most adults, but no consistent correlation between antibodies and caries prevalence among adults has been found [reviews in Brandtzaeg, 1983;Krasse et al, 1987], Also, studies on the possible association be tween antibodies and dental caries in children have proved equivocal [Tenovuo, 1986], In children, natu rally occurring salivary IgA antibodies seem to offer no protection against colonization of MS and/or against dental caries [Camling and Köhler, 1987;Ri viere and Papagiannoulis, 1987;Tenovuo et al, 1987;Aaltonen et al, 1988] whereas specific serum IgG an tibodies against S. mutans are often associated with low caries activity Aaltonen et al, 1987;Tenovuo et al, 1987]. Most of these analyses have been done using whole cells of S. mutans as anti gens which may lead to erroneous results because of possible cross-reactivity between various oral bacte ria, particularly streptococci [Bammann and Gib bons, 1979;Luo et al, 1988],…”

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confidence: 99%

Caries Development in Children in Relation to the Presence of Mutans Streptococci in Dental Plaque and of Serum Antibodies against Whole Cells and Protein Antigen I/II of Streptococcus mutans

Tenovuo¹,

Lehtonen

Aaltonen³

1990

Caries Res

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Twenty-eight children, aged 0.8–3.8 years, were studied with respect to the presence of mutans streptococci (MS) in dental plaque and the amount and avidity of specific serum IgG and IgM antibodies against whole cells and streptococcal protein antigen I/II (SA I/II) of Streptococcus mutans. The presence or absence of MS in dental plaque at the median age of 1.9 years predicted the caries development during a 2.7-year follow-up period with a sensitivity and specificity of 73 and 92%, respectively. The caries predictive value of a positive finding of MS at this age was as high as 92%. Almost all children had detectable amounts of serum IgG and IgM antibodies against whole cells and SA I/II of S. mutans, irrespective of the presence of detectable levels of this bacterium in dental plaque. These antibodies increased with age. The antibody levels did not differ significantly between children who were MS-negative or MS-positive. However, in MS-free children as well as in the whole study group, total specific and high-avidity antibodies of IgG class against whole cells correlated positively with antibodies against SA I/II. In MS-infected children such an association was observed for IgM but not for IgG antibodies. This different serum antibody profile in MS-negative and -positive children may be related to the mode of immunization with S. mutans.

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Antibodies to the oral bacterium Streptococcus mutans and the development of caries in children in relation to maternal dental treatment during pregnancy

Cited by 13 publications

References 28 publications

Are Mutans Streptococci Detected in Preschool Children a Reliable Predictive Factor for Dental Caries Risk? A Systematic Review

Are Mutans Streptococci Detected in Preschool Children a Reliable Predictive Factor for Dental Caries Risk? A Systematic Review

Maternal caries incidence and salivary close‐contacts with children affect antibody levels to Streptococcus mutans in children

Caries Development in Children in Relation to the Presence of Mutans Streptococci in Dental Plaque and of Serum Antibodies against Whole Cells and Protein Antigen I/II of Streptococcus mutans

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