Antibodies to the Ross River Virus in Captive Marsupials in Urban Areas of Eastern New South Wales, Australia

Old, Julie M.; Deane, Elizabeth M.

doi:10.7589/0090-3558-41.3.611

Cited by 17 publications

(13 citation statements)

References 10 publications

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“…A serosurvey of captive marsupials undertaken in urban New South Wales demonstrated that tammar wallabies (M. eugenuii) were commonly infected by RRV (Old and Deane 2005). These data support the possibility of marsupials serving as amplifying hosts for RRV in urban areas in Australia.…”

Section: Potter Et Almentioning

confidence: 73%

The Seroprevalence and Factors Associated with Ross River Virus Infection in Western Grey Kangaroos (Macropus fuliginosus) in Western Australia

Potter

Johansen²,

Fenwick³

et al. 2014

Vector-Borne and Zoonotic Diseases

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A serosurvey was undertaken in 15 locations in the midwest to southwest of Western Australia (WA) to investigate the seroprevalence of Ross River virus (RRV) neutralizing antibodies and factors associated with infection in western grey kangaroos (Macropus fuliginosus). The estimated seroprevalence in 2632 kangaroo samples, using a serum neutralization test, was 43.9% (95% CI 42.0, 45.8). Location was significantly associated with seroprevalence ( p < 0.001). There was a strong positive correlation between seroprevalence and the average log-transformed neutralizing antibody titer (r = 0.98, p < 0.001). The seroprevalence among adult kangaroos was significantly higher than in subadult kangaroos ( p < 0.05). No significant association was observed between seroprevalence and the sex of kangaroos ( p > 0.05). The results of this study indicate that kangaroos in WA are regularly infected with RRV and may be involved in the maintenance and transmission of RRV.

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Section: Potter Et Almentioning

confidence: 73%

The Seroprevalence and Factors Associated with Ross River Virus Infection in Western Grey Kangaroos (Macropus fuliginosus) in Western Australia

Potter

Johansen²,

Fenwick³

et al. 2014

Vector-Borne and Zoonotic Diseases

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“…Like all alphaviruses, the virus is maintained in transmission cycles between its mosquito vector and vertebrate hosts. In the case of RRV the predominant vectors are the mosquitoes Culex annulirostris and Aedes vigilax and the vertebrate hosts are commonly found to be native marsupials (Harley et al, 2001;Old & Deane, 2005;Oliveira et al, 2006). In Australia, there are between 5,000 to 8,000 cases of RRV reported annually (Harley et al, 2001), with patients displaying symptoms of arthritis, arthralgia, myalgia, fatigue, febrile illness and rash (Fraser, 1986;Harley et al, 2002;Harley et al, 2001).…”

Section: Ross River Virus (Rrv)mentioning

confidence: 99%

Arthrogenic Alphaviruses and Inflammatory Myopathies

Herrero¹,

Mahalingam²

2011

Idiopathic Inflammatory Myopathies - Recent Developments

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“…RRV is a positive-sense RNA virus that circulates endemically in Australia and the South Pacific (4) and is maintained in transmission cycles between its mosquito vector and vertebrate hosts (13). In Australia, roughly 5,000 cases of RRV are reported annually (4), with symptoms of arthritis, arthralgia, myalgia, fatigue, febrile illness, and rash (4,14,15).…”

mentioning

confidence: 99%

Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis

Herrero

Nelson

Srikiatkhachorn

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Arthrogenic alphaviruses, such as Ross River virus (RRV), chikungunya, Sindbis, mayaro and o'nyong-nyong viruses circulate endemically worldwide, frequently causing outbreaks of polyarthritis. The exact mechanisms of how alphaviruses induce polyarthritis remain ill defined, although macrophages are known to play a key role. Macrophage migration inhibitory factor (MIF) is an important cytokine involved in rheumatoid arthritis pathogenesis. Here, we characterize the role of MIF in alphavirus–induced arthritides using a mouse model of RRV-induced arthritis, which has many characteristics of RRV disease in humans. RRV-infected WT mice developed severe disease associated with up-regulated MIF expression in serum and tissues, which corresponded to severe inflammation and tissue damage. MIF-deficient (MIF −/− ) mice developed mild disease accompanied by a reduction in inflammatory infiltrates and muscle destruction in the tissues, despite having viral titers similar to WT mice. In addition, reconstitution of MIF into MIF −/− mice exacerbated RRV disease and treatment of mice with MIF antagonist ameliorated disease in WT mice. Collectively, these findings suggest that MIF plays a critical role in determining the clinical severity of alphavirus–induced musculoskeletal disease and may provide a target for the development of antiviral pharmaceuticals. The prospect being that early treatment with MIF-blocking pharmaceuticals may curtail the debilitating arthritis associated with alphaviral infections.

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Antibodies to the Ross River Virus in Captive Marsupials in Urban Areas of Eastern New South Wales, Australia

Cited by 17 publications

References 10 publications

The Seroprevalence and Factors Associated with Ross River Virus Infection in Western Grey Kangaroos (Macropus fuliginosus) in Western Australia

The Seroprevalence and Factors Associated with Ross River Virus Infection in Western Grey Kangaroos (Macropus fuliginosus) in Western Australia

Arthrogenic Alphaviruses and Inflammatory Myopathies

Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis

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