Antibody and cell-mediated immune response to whole virion and split virion influenza vaccine in patients with inflammatory bowel disease on maintenance immunosuppressive and biological therapy

Abstract

Split virion vaccines seem to be more effective than whole virion vaccines. Measuring the antibody responses is worthwhile in patients treated with immunosuppressants to determine the efficacy of influenza vaccination.

Canadian Association of Gastroenterology Clinical Practice Guideline for Immunizations in Patients With Inflammatory Bowel Disease (IBD)—Part 2: Inactivated Vaccines

“…The 2 systematic reviews in healthy adults, and the 10 other studies in adults with IBD showed no serious adverse events associated with the use of inactivated influenza vaccine. 88,89,[91][92][93][94][95][96][97][98][99][100] The evidence for efficacy and safety were anchored to the general population. The CoE for efficacy remained moderate because studies suggesting reduced immunogenicity in patients with IBD showed that the European Union Committee for Medicinal Products for Human Use criteria for effective immunogenicity were met in the majority of patients.…”