2024
DOI: 10.1101/2024.04.02.587719
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Antibody-dependent Intracellular neutralisation by TRIM21 is potentiated by HOIP and linear ubiquitin chains

Christopher Green,
Konstanze F. Winklhofer,
Adam J. Fletcher
et al.

Abstract: Antibody-dependent intracellular neutralisation (ADIN) promotes the rapid proteasomal degradation of viruses and other large substrates in the cytosol. It is dependent on detection of intracellular virus-bound antibodies by the Fc receptor and E3 ligase TRIM21, followed by disassembly of the virus by the unfoldase VCP/p97. It is not known how VCP is recruited to TRIM21. We performed a limited siRNA knock- down screen of known VCP adaptors to determine their involvement in ADIN. Knock- down of HOIP, the only ub… Show more

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