Antibody discovery using microfluidic systems

Simutis, Karolis; Stonyte, Greta; Mažutis, Linas

doi:10.1016/b978-0-12-812659-2.00012-0

Cited by 4 publications

(5 citation statements)

References 45 publications

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“…Moreover, the release of the drug substances can be programmed by manipulating the physical and chemical properties of the polypeptide structure [ 68 ]. Antibodies discovery and cell delivery are other significant applications where microfluidics are being employed [ 172 , 173 ].…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

Controlled Drug Delivery Systems: Current Status and Future Directions

2021

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The drug delivery system enables the release of the active pharmaceutical ingredient to achieve a desired therapeutic response. Conventional drug delivery systems (tablets, capsules, syrups, ointments, etc.) suffer from poor bioavailability and fluctuations in plasma drug level and are unable to achieve sustained release. Without an efficient delivery mechanism, the whole therapeutic process can be rendered useless. Moreover, the drug has to be delivered at a specified controlled rate and at the target site as precisely as possible to achieve maximum efficacy and safety. Controlled drug delivery systems are developed to combat the problems associated with conventional drug delivery. There has been a tremendous evolution in controlled drug delivery systems from the past two decades ranging from macro scale and nano scale to intelligent targeted delivery. The initial part of this review provides a basic understanding of drug delivery systems with an emphasis on the pharmacokinetics of the drug. It also discusses the conventional drug delivery systems and their limitations. Further, controlled drug delivery systems are discussed in detail with the design considerations, classifications and drawings. In addition, nano-drug delivery, targeted and smart drug delivery using stimuli-responsive and intelligent biomaterials is discussed with recent key findings. The paper concludes with the challenges faced and future directions in controlled drug delivery.

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Section: Challenges and Future Directionsmentioning

confidence: 99%

Controlled Drug Delivery Systems: Current Status and Future Directions

2021

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“…151 Choosing a particular antibody discovery platform thus requires carefully considering the cost and benefits of each separation technique together with detecting a desired antibody function and its frequency in a biological repertoire. 47,82 Overall, methods to increase sensitivity, specificity and/or multiple-parameter technologies are growing more dominant in microfluidics, for instance, by incorporating affinity or epitope mapping measurement into the screening process, as they allow a much more refined, qualitative search for potential candidates not only based on antigen binding alone.…”

Section: Future Developments and Outlookmentioning

confidence: 99%

“…Most general antibody discovery platforms usually start with approaches that separate antibody-producing moieties into individual containers to diverge the spectrum of present antibodies into their monoclonal form. 81,82 After isolation and antibody detection, the next key step in the discovery is the isolation, sorting or physical removal of cells producing antibodies of interest from the analyzed repertoire (see Fig. 2), 83 and certain techniques, such as antibody display, directly start at this step.…”

Section: Overview Of Technologies Enabling Microfluidic Discovery Of ...mentioning

confidence: 99%

Section: Future Developments and Outlookmentioning

confidence: 99%

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Antibodies, repertoires and microdevices in antibody discovery and characterization

Schlotheuber,

Lüchtefeld,

Eyer

2024

Lab Chip

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“…Furthermore, by modifying the chemical and physical features of the polypeptide structure, the release of the pharmacological compounds can be controlled [29]. Microfluidics is also being used for important purposes including finding new antibodies and transporting cells [30,31].…”

Section: Microfluidics In Cddsmentioning

confidence: 99%

Formulation Development & Evaluation of Controlled Drug Delivery System: An Overview

Paul

Ahmed

Hasan

et al. 2022

clin. med. & helt. res. jour.

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The therapeutic effect is brought about by the drug delivery system dispensing the active medicinal ingredient. Due to fluctuations in plasma drug levels, traditional drug delivery devices have poor bioavailability and cannot generate a continuous release. The drug must also be supplied at a tightly regulated rate and to the correct location for it to be most effective and safe. To solve the problems inherent in the current methods of administering medication, scientists are working on perfecting controlled drug delivery systems. Controlled pharmaceutical delivery systems have come a long way in the last twenty years, from bulk distribution to nanoscale precision to smart, patient-specific dosing. The paper's initial portion provides background knowledge on drug delivery methods, emphasizing pharmacokinetics. The article also discusses the pros and cons of more conventional drug delivery methods. Controlled drug delivery systems' design factors, categorizations, and schematics are also discussed in length. In addition, recent advances in nano-drug delivery, targeted, and innovative drug delivery utilizing stimuli-responsive, intelligent biomaterials are discussed. The limitations of regulated medicine distribution and some possible solutions are discussed at the end of the study.

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Antibody discovery using microfluidic systems

Cited by 4 publications

References 45 publications

Controlled Drug Delivery Systems: Current Status and Future Directions

Controlled Drug Delivery Systems: Current Status and Future Directions

Antibodies, repertoires and microdevices in antibody discovery and characterization

Formulation Development & Evaluation of Controlled Drug Delivery System: An Overview

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