Antibody forming cell response to nickel and nickel-coated fly ash in rats

Abstract

<jats:p> The potential of nickel as nickel chloride, native fly ash and Ni-coated fly ash to alter pulmonary and systemic immune response was evaluated upon intratracheal (I/T) exposure of rats. The animals were sensitised with sheep red blood cells (SRBC) through I/T and intraperitoneal (I/P) routes. Nickel exposure resulted in a decrease in the number of antibody forming cells (AFC) in lung associated lymph nodes (LALN) and spleen. In rats exposed to native fly ash there was a reduction in the number of AFC in LALN but not in spleen. The results did not demonstrate any significant difference in the immunosuppression of fly ash and Ni-coated fly ash exposed rats. The decrease in AFC formation in Ni-coated fly ash exposed animals was of a lesser magnitude than in rats exposed to Ni-alone. </jats:p>

The protective effect of Zinc and Magnesium against subchronic Cadmium toxicity in Wistar rats (Biochemical and neurobehavioral effects)

“…This increase in exploration is explained by the action of heavy metals (cadmium) on the dopaminergic system which results in an increase in synthesis, release of the neurotransmitter, and hyperfunctioning postsynaptic receivers [75].…”