Antibody glycosylation directs innate and adaptive immune collaboration

Signaling pathways governing the behaviors of leukemia stem cells

“… 143 BMI-1-deficient mice showed engraftment and proliferative disability and stimulated differentiation and apoptosis in AML stem/progenitor cells. 144 , 145 BMI-1 and Ring1b can organize a heterodimeric complex that is involved in the initiation and maintenance of LSCs. Epigenetic inhibition of BMI-1, including methylation, histone deacetylase, and ubiquitin-proteasome could be utilized as anti-BMI-1 insights in LSCs.…”

Glycosylation modification patterns reveal distinct tumor metabolism and immune microenvironment landscape in lower-grade gliomas

“…Also, these changes of glycosylation also cause abnormal expression of membrane-localized glycans, which will trigger cellular malignant transformation and mediate cancer cell proliferation, survival, and metastasis ( Marsico et al, 2018 ; Chandler et al, 2019 ; Thomas et al, 2021 ). Accumulating findings suggest that abnormal glycan profiles could regulate the microenvironment and immune response ( Mereiter et al, 2019 ) and even hinder an effective immune response ( Polmear and Good-Jacobson, 2021 ). In addition, the metabolic state ( Campbell and Wellen, 2018 ) or metabolic reprogramming ( Carvalho-Cruz et al, 2018 ) of the tumor cell can lead to aberrant glycosylation intra- and extra-cellular.…”