Abstract:We have used a patented (US 8,745,713) in vitro antibody platform technology to isolate fully human antibodies against a novel B cell lymphoma secreted biomarker, which is an isoform of the Fc Receptor-Like (FCRL) protein family. The FCRL isoform appears to inhibit CD4+ T cell recognition, and consequently would obstruct T cell immunosurveillance of B cell lymphoma. Targeted antibody immunotherapy is now a first-line treatment of B cell lymphoma due to the success of rituximab, a chimeric antibody that binds t… Show more
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