Antibody levels for cytomegalovirus, herpes simplex virus, and rubella in patients with acquired immune deficiency syndrome

Halbert, Seymour P.; Kiefer, D; Friedman‐Kien, Alvin E.; Poiesz, BJ

doi:10.1128/jcm.23.2.318-321.1986

Cited by 21 publications

(3 citation statements)

References 20 publications

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“…However, the finding that AIDS-P. carinii pneumonitis patients, CPDs, and particularly homosexual males, had significantly lower anti-P. carinii titers was of interest. Significantly lower titers in AIDS-P. carinii pneumonitis patients were not anticipated because polyclonal hypergammaglobulinemia has emerged as a prominent feature of AIDS (1, 7) and because antibody titers to both herpes simplex virus and cytomegalovirus have been reported to be elevated in AIDS patients (8). However, the findings in the present study are more consistent with those of Roberts (24), who described depressed antibody titers to Coccidioides immitis in patients with AIDS.…”

Section: Resultssupporting

confidence: 83%

Evidence for depressed humoral immunity to Pneumocystis carinii in homosexual males, commercial plasma donors, and patients with acquired immunodeficiency syndrome

Pifer¹,

Niell

Langdon

et al. 1987

J Clin Microbiol

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Section: Resultssupporting

confidence: 83%

Evidence for depressed humoral immunity to Pneumocystis carinii in homosexual males, commercial plasma donors, and patients with acquired immunodeficiency syndrome

Pifer¹,

Niell

Langdon

et al. 1987

J Clin Microbiol

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“…AIDS patients were included in this study because the severe immunosuppression caused by viral infection in the lymphocytes might influence the serologic response to CMV during the terminal stage when elevated levels of antibodies to CMV are found (7). The serologic picture was rather uniform, with all patients having CF antibodies to CMV.…”

Section: Discussionmentioning

confidence: 99%

Kinetics of specific immunoglobulins M, E, A, and G in congenital, primary, and secondary cytomegalovirus infection studied by antibody-capture enzyme-linked immunosorbent assay

1988

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Antibody-capture enzyme-linked immunosorbent assay (ELISA) using enzyme-labeled cytomegalovirus (CMV) nuclear antigen is a reliable and easily performed test suitable for routine use. As the serologic response to CMV infection may, however, vary considerably among patients, we have studied the kinetics of CMV-specific immunoglobulin M (IgM), IgE, IgA, and IgG antibodies in 352 sera from 61 patients by using antibody-capture ELISA and complement fixation (CF) tests. In a CMV mononucleosis group (n = 17), most patients had antibodies of all four immunoglobulin classes, but antibody levels decreased rapidly, with half the patients having a borderline-positive or a negative reaction for all classes, except IgG, 2 months after the appearance of symptoms. Twelve patients with a primary CMV infection after renal or bone marrow transplantation also developed all immunoglobulin-class antibodies. In only two patients did CMV IgM and IgE antibodies precede seroconversion of CF antibodies, and in one patient, these antibodies lagged months behind. Most patients had all classes of CMV antibodies, except IgA, for a year or more. Among 10 transplant patients with a secondary CMV infection, 50% had long-lasting IgM antibodies, and very few had IgE or IgA antibodies, but all had IgG antibodies to CMV. In 13 infected infants, the CMV-specific serologic response was also characterized by long-lasting IgM, IgE, and IgG antibodies. Two patients did not develop detectable IgM antibodies, and one of these did not show IgE antibodies either. The IgA response in infants as a whole was * Corresponding author.

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“…Previous studies on serological responses to EBV and CMV in HIV positive patients demonstrated a high prevalence of specific antibodies and higher antibody titres as compared to HIV negative patients [Sumaya et al, 1986;Halbert et al, 19861. Nevertheless, these studies were based on the clinical assessment of patients and not on the absolute CD4 counts as prognostic indicators.…”

Section: Antibodies To Cytomegalovirusmentioning

confidence: 99%

Antibodies to Epstein‐Barr virus and cytomegalovirus in relation to CD4 cell number in human immunodeficiency virus 1 infection

Quesnel¹,

Pozzetto²,

Touraine

et al. 1992

Journal of Medical Virology

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Interaction between herpesviruses and human immunodeficiency virus (HIV)1 is postulated in the progression of HIV disease. In order to evaluate the specific antibody responses directed to Epstein-Barr virus (EBV) and cytomegalovirus (CMV) and to provide serological evidence suggesting reactivation of these viruses able to accelerate the immunodeficiency, we studied IgA and IgG titres to EBV and CMV in the serum of HIV positive patients in relation to the CD4 cell number. The titres of IgG antibodies to EBV and the prevalence of IgG to CMV were significantly higher in HIV positive patients compared to control high risk HIV negative subjects. In HIV infected patients, anti-VCA IgG antibodies increased and anti-EBNA IgG antibodies decreased progressively in relation to the decline of CD4 cell number whereas anti-CMV IgG antibodies did not varied significantly at the same time. Anti-VCA IgA and anti-EA IgG antibodies were found uncommonly and with low titres. IgA antibodies to EA and CMV were not detected in any patient. The variations in EBV antibody response that we describe in HIV infection were previously reported in other immunodeficiency states and could be distinctive of these diseases.

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Antibody levels for cytomegalovirus, herpes simplex virus, and rubella in patients with acquired immune deficiency syndrome

Cited by 21 publications

References 20 publications

Evidence for depressed humoral immunity to Pneumocystis carinii in homosexual males, commercial plasma donors, and patients with acquired immunodeficiency syndrome

Evidence for depressed humoral immunity to Pneumocystis carinii in homosexual males, commercial plasma donors, and patients with acquired immunodeficiency syndrome

Kinetics of specific immunoglobulins M, E, A, and G in congenital, primary, and secondary cytomegalovirus infection studied by antibody-capture enzyme-linked immunosorbent assay

Antibodies to Epstein‐Barr virus and cytomegalovirus in relation to CD4 cell number in human immunodeficiency virus 1 infection

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