Antibody-mediated bacterial adhesion to cytomegalovirus-induced Fc receptors. Potential relationship to secondary infections complicating herpesvirus infections.

Mackowiak, Philip A.; Marling-Cason, Margaret; Smith, Jerry W.; Luby, James P.

doi:10.1172/jci111324

Cited by 14 publications

(12 citation statements)

References 19 publications

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“…Also, herpesviruses may promote bacterial colonization, as indicated by a 10‐fold increase in the in vitro adherence of a uropathogenic strain of Escherichia coli to human bladder cells preinfected with HSV‐2 (42). In addition, HCMV‐induced Fc receptors may form the basis for antibody‐mediated bacterial adhesion (20).…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus periodontal presence is associated with subgingival Dialister pneumosintes and alveolar bone loss

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Kamma³

2002

Oral Microbiology and Immunology

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Destructive periodontal disease is associated with human cytomegalovirus (HCMV), Epstein-Barr type 1 virus (EBV-1) and other members of the Herpesviridae family as well as with various gram-negative anaerobic bacteria, including the Dialister pneumosintes species. This study aimed to determine possible interrelationships between periodontal HCMV, EBV-1, herpes simplex virus and D. pneumosintes, and relate the microbiological findings to periodontitis clinical status. Sixteen subjects each contributed paper point samples from two progressing and two stable periodontitis lesions, as determined by ongoing loss of probing attachment. Polymerase chain reaction methodology was used to identify the study herpesviruses and D. pneumosintes. Chi-squared tests, Fisher exact tests and multivariate logistic regression were employed to identify statistical associations among herpesviruses, bacteria and clinical variables. HCMV, and no other virus or combination of viruses, was positively associated with the presence of D. pneumosintes, and the relationship was specific for individual periodontitis sites with no detectable subject effect. D. pneumosintes was in turn positively associated with periodontal pocket depth and disease-active periodontitis. When the average percentage of alveolar bone loss in all teeth was treated as a response, HCMV remained significant even after D. pneumosintes was included in the model, suggesting that both HCMV and D. pneumosintes affected bone loss or, alternatively, HCMV affected factors not studied that themselves can induce bone loss. We hypothesize that periodontal HCMV sets the stage for subgingival proliferation of D. pneumosintes and subsequent periodontal disease progression. Studies on herpesviral-bacterial interactions may hold great promise for delineating important etio-pathogenic aspects of destructive periodontal disease.

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Section: Discussionmentioning

confidence: 99%

Cytomegalovirus periodontal presence is associated with subgingival Dialister pneumosintes and alveolar bone loss

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Kamma³

2002

Oral Microbiology and Immunology

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“…Cytomegalovirus and other viruses in the herpes group induce Fc receptors in host cells during the process of parasitization (10,14,17,21). These receptors bind IgG derived from various animals, as well as purified Fc fragments, but do not bind nonimmune IgG Fab fragments, or IgA or IgM (7,10).…”

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confidence: 99%

Immunoreactivity of Cytomegalovirus‐Induced Fc Receptors

Mackowiak¹,

Marling-Cason

1987

Microbiology and Immunology

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The present studies were undertaken to characterize the affinity of CMV-induced Fc receptors for each of the subclasses of human IgG and to define the specific region of the IgG Fc fragment interacting with such receptors. To do this, we infected confluent human embryonic lung (HEL) cell monolayers with CMV (strain AD169) and then used a double radiolabel assay to measure adherence of antibody-coated E. coli 06 to such monolayers. Preincubating monolayers with each of the 4 subclasses of human IgG (but not IgA, IgM, or human or bovine albumin) abrogated the enhancing effect of CMV infection on adherence of antibody-coated E. coli 06 to HEL monolayers. Pepsin-derived, purified Fc fragments of human IgG had a similar abrogative effect. Preincubating these with staphylococcal protein A did not reduce their capacity to interfere with binding of antibody-coated E. coli to CMV-induced Fc receptors. These observations establish a broad range of immunoreactivity for CMV-induced Fc receptors, that encompasses all 4 subclasses of human IgG. They also provide indirect evidence that the reaction site of CMV-induced Fc receptors is in the CH2 domain of the Fc fragment.

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“…The main risk factors include severe neutropenia (absolute neutrophil count of <500/ml lasting for 1 week), vascular and urinary catheters, disruption of gastrointestinal or oropharyngeal mucosa by chemotherapy, use of broad‐spectrum antibiotics and therapy with high‐dose corticosteroids for GVHD 16 . In addition, CMV infection can affect the host defense system and may increase the risk of opportunistic infections in the immunocompromised transplant patient 17–20 . Our patient possessed several of these risk factors including history of BMT with neutropenia and a history of GVHD with use of corticosteroids and broad‐spectrum antibiotics.…”

Section: Discussionmentioning

confidence: 96%

Disseminated Scopulariopsis–culture is required to distinguish from other disseminated mould infections

Swick¹,

Reddy²,

Friedrichs³

et al. 2010

J Cutan Pathol

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Disseminated fungal infections are a major cause of mortality in severely immunocompromised bone marrow transplant (BMT) patients. Scopulariopsis is a soil saprophytic mould that is typically associated with onychomycosis and only rarely associated with disseminated infection with cutaneous findings. We describe a case of fatal disseminated Scopulariopsis infection in a 56-year-old neutropenic male with chronic myelogenous leukemia status post peripheral blood stem cell transplant that was clinically and histologically indistinguishable from disseminated Aspergillus, Fusarium or zygomycosis infection. Distinguishing the above listed fungi by tissue culture is crucial because disseminated Scopulariopsis is difficult to eradicate and associated with a high mortality rate in the immunocompromised BMT patient population.

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Antibody-mediated bacterial adhesion to cytomegalovirus-induced Fc receptors. Potential relationship to secondary infections complicating herpesvirus infections.

Cited by 14 publications

References 19 publications

Cytomegalovirus periodontal presence is associated with subgingival Dialister pneumosintes and alveolar bone loss

Cytomegalovirus periodontal presence is associated with subgingival Dialister pneumosintes and alveolar bone loss

Immunoreactivity of Cytomegalovirus‐Induced Fc Receptors

Disseminated Scopulariopsis–culture is required to distinguish from other disseminated mould infections

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