Antibody persistence after two vaccinations with either FSME-IMMUN® Junior or ENCEPUR® Children followed by third vaccination with FSME-IMMUN® Junior

Five year follow-up after primary vaccination against tick-borne encephalitis in children

“…While the findings from the present study are consistent with a number of previous reports that have demonstrated that Encepur ® Children elicits a stronger immune response compared to FSME-IMMUN ® Junior [9,16], it is important to note that other reports have shown the reverse [10,17]. Nevertheless, the common conclusion from all these studies is that despite being considered analogous vaccines, the immune responses to Encepur ® Children and FSME-IMMUN ® Junior are not identical.…”

“…Three doses of TBE vaccination are required for immunogenicity (priming) and can be administered according to a 'conventional' schedule (Encepur ® Children: injections on Day 0, at 1-3 months and 9-12 months; FSME-IMMUN ® Junior: injections on Day 0, at 1-3 months, and 5-12 months) [1], or an 'accelerated conventional' schedule (Encepur ® Children: doses on Days 0, 14 and at 9-12 months; FSME-IMMUN ® Junior: injection on Days 0, 14, and at 5-12 months). Clinical studies to date have already established the immunogenicity and safety of both pediatric vaccines [3,9,10], and some have even demonstrated that Encepur ® Children and FSME-IMMUN ® Junior can be successfully interchanged during the primary vaccination series [10,11]. For example, in the parent study to this investigation [9], it was demonstrated that a primary vaccination course initiated with FSME-IMMUN ® Junior (two doses) could be effectively completed with Encepur ® Children (one dose).…”

“…For example, in the parent study to this investigation [9], it was demonstrated that a primary vaccination course initiated with FSME-IMMUN ® Junior (two doses) could be effectively completed with Encepur ® Children (one dose). Likewise, it has been shown that a primary vaccination course initiated with Encepur ® Children (two doses) can be effectively completed with FSME-IMMUN ® Junior (one dose) [10]. Regardless of vaccine used, however, a booster dose is recommended 3 years after a primary immunization series following a conventional schedule.…”

Epidemiology of tick-borne encephalitis (TBE) in Europe and its prevention by available vaccines

“…Regarding the two above-mentioned vaccines, a dose of either one may be successfully followed by a dose of the other, as shown by Prymula et al 98 Thus, subjects who received either FSME-Immun® Junior or Encepur® Children vaccine for the first two vaccinations and FSME-Immun® Junior for the third showed a comparably strong immune response, regardless of the previous TBE vaccine administered 98 …”

Epidemiological and Ecological Studies of Tick-borne Encephalitis Virus

“…The FSME-IMMUN and Encepur vaccines are interchangeable and doses of either vaccine can successfully be followed by the other [208].…”