Antibody reactivities to tumor-suppressor protein p53 and HTLV-I Tof, Rex and Tax in HTLV-I-infected people with differing clinical status

Chen, Yi Ming A.; Chen, Shiu Hung; Fu, Chong Yau; Chen, Jeou Yuan; Osame, Mitsuhiro

doi:10.1002/(sici)1097-0215(19970410)71:2<196::aid-ijc12>3.0.co;2-g

Cited by 28 publications

(10 citation statements)

References 32 publications

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“…Even though detecting the actual proteins has been difficult, mRNA has been detected by RT-PCR and QC-PCR [119]. Patients also possess antibodies and cytotoxic T-cells (CTLs) directed against these proteins [134,135]. ORF I genes appear to be expressed 100–1000 times less than ORF III and IV genes and ORF II genes are expressed 500–2500 times less than ORF III and IV genes [136].…”

Section: Nonstructural Proteins Of Htlv-1: Essential Role In Viral Spmentioning

confidence: 99%

Molecular Determinants of Human T-lymphotropic Virus Type 1 Transmission and Spread

Lairmore

Anupam

Bowden

et al. 2011

Viruses

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Human T-lymphotrophic virus type-1 (HTLV-1) infects approximately 15 to 20 million people worldwide, with endemic areas in Japan, the Caribbean, and Africa. The virus is spread through contact with bodily fluids containing infected cells, most often from mother to child through breast milk or via blood transfusion. After prolonged latency periods, approximately 3 to 5% of HTLV-1 infected individuals will develop either adult T-cell leukemia/lymphoma (ATL), or other lymphocyte-mediated disorders such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The genome of this complex retrovirus contains typical gag, pol, and env genes, but also unique nonstructural proteins encoded from the pX region. These nonstructural genes encode the Tax and Rex regulatory proteins, as well as novel proteins essential for viral spread in vivo such as, p30, p12, p13 and the antisense encoded HBZ. While progress has been made in the understanding of viral determinants of cell transformation and host immune responses, host and viral determinants of HTLV-1 transmission and spread during the early phases of infection are unclear. Improvements in the molecular tools to test these viral determinants in cellular and animal models have provided new insights into the early events of HTLV-1 infection. This review will focus on studies that test HTLV-1 determinants in context to full length infectious clones of the virus providing insights into the mechanisms of transmission and spread of HTLV-1.

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Section: Nonstructural Proteins Of Htlv-1: Essential Role In Viral Spmentioning

confidence: 99%

Molecular Determinants of Human T-lymphotropic Virus Type 1 Transmission and Spread

Lairmore

Anupam

Bowden

et al. 2011

Viruses

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“…It should be noted that the in vitro infectivity of p30-ablated HTLV-1 was not sustained over time in primary dendritic cell [35]. Other observations, such as the presence of antibodies to p30 during infection may provide evidence of the importance of p30 in vivo [32,104]. It was first shown that the ablation of p30 expression in vivo result is a dramatic decrease of HTLV-1 viral load in a rabbit model [32].…”

Section: Htlv-1 P30mentioning

confidence: 99%

“…CTLs and antibodies that recognize orf-II peptides can be detected in HTLV-1-infected individuals, suggesting that p13 may have an important role in vivo [104,117]. In an early study to examine the role of p13 alone in vivo , a molecular clone of HTLV-1 mutated to selectively ablate p13 failed to establish viral infection in a rabbit model [118].…”

Section: Htlv-1 P13mentioning

confidence: 99%

Orf-I and Orf-II-Encoded Proteins in HTLV-1 Infection and Persistence

Edwards

Fenizia

Gold

et al. 2011

Viruses

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The 3′ end of the human T-cell leukemia/lymphoma virus type-1 (HTLV-1) genome contains four overlapping open reading frames (ORF) that encode regulatory proteins. Here, we review current knowledge of HTLV-1 orf-I and orf-II protein products. Singly spliced mRNA from orf-I encodes p12, which can be proteolytically cleaved to generate p8, while differential splicing of mRNA from orf-II results in production of p13 and p30. These proteins have been demonstrated to modulate transcription, apoptosis, host cell activation and proliferation, virus infectivity and transmission, and host immune responses. Though these proteins are not essential for virus replication in vitro, p8, p12, p13, and p30 have an important role in the establishment and maintenance of HTLV-1 infection in vivo.

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“…pX ORFs I and II mRNAs are present in infected cell lines and freshly isolated cells from HTLV-1-infected subjects [9], as well as in ATL and HAM/TSP patients [10]. Antibodies [11,12] and cytotoxic T cells [13] that recognize recombinant proteins or peptides of the pX ORF I and II proteins are present in HTLV-1 infected patients and asymptomatic carriers.…”

Section: Introductionmentioning

confidence: 99%

Human T lymphotropic virus type-1 p30II alters cellular gene expression to selectively enhance signaling pathways that activate T lymphocytes

et al. 2004

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We are the first to demonstrate that p30II, while repressing the expression of many genes, selectively activates key gene pathways involved in T-cell signaling/activation. Collectively, our data suggests that this complex retrovirus, associated with lymphoproliferative diseases, relies upon accessory gene products to modify cellular environment to promote clonal expansion of the virus genome and thus maintain proviral loads in vivo.

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Antibody reactivities to tumor-suppressor protein p53 and HTLV-I Tof, Rex and Tax in HTLV-I-infected people with differing clinical status

Abstract: Since the presence of anti-p53 antibody has been correlated with the mutation and accumulation of p53, the aim of this study was to detect anti-p53 antibody and understand its correlations with anti-Tof, -Rex, or - Tax

Cited by 28 publications

References 32 publications

Molecular Determinants of Human T-lymphotropic Virus Type 1 Transmission and Spread

Molecular Determinants of Human T-lymphotropic Virus Type 1 Transmission and Spread

Orf-I and Orf-II-Encoded Proteins in HTLV-1 Infection and Persistence

Human T lymphotropic virus type-1 p30II alters cellular gene expression to selectively enhance signaling pathways that activate T lymphocytes

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