Antibody removal therapy in transplantation

Higgins, Robert; Bevan, D. J.

doi:10.1016/0955-470x(95)80003-q

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What Are the Antibody Barriers?1

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“…There are two types of antibodies of particular importance in transplantation. Many other antibodies have been reported to cause rejection in isolated cases, but these will not be considered here (Higgins & Bevan 1995; Gloor 2005; Zachary et al . 2007).…”

Section: What Are the Antibody Barriers?mentioning

confidence: 99%

New Choices for Patients Needing Kidney Transplantation Across Antibody Barriers

Higgins

Hathaway²,

Lowe³

et al. 2008

Journal of Renal Care

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Antibodies in the blood of a kidney transplant recipient can provide a barrier to transplantation, which is additional to the usual possibility of cellular rejection. The antibodies most frequently encountered are ABO (blood group) and human leucocyte antigen (HLA) (tissue-type) antibodies. About 250 living donor transplants each year in the United Kingdom have been stopped because of an antibody barrier. It is now possible to offer a choice of treatment modalities to these people, including exchange transplantation and antibody-incompatible transplantation. It is likely that both schemes will complement each other and both are available in the United Kingdom.

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Section: What Are the Antibody Barriers?mentioning

confidence: 99%