Antibody response of sheep to simultaneous vaccine administration of foot and mouth disease, blue tongue, peste des pestits ruminants , and sheep-goat pox antigens

Abstract

There are many infectious animal diseases in Turkey and generally vaccination is the prime control strategy to combat them. However, it is difficult to apply all vaccines in a definite period in the field due to limitations of the labor and finance. The rapid vaccination and effective use of labor can be possible with the help of simultaneous vaccines administrations. The aim of the study is to show the effects of simultaneous foot-and-mouth disease (FMD), peste des pestits ruminants (PPR), sheep-goat pox (SGP) and bluetongue (BT) vaccine administration on the antibody response of sheep. For this aim, 30 sheep were divided in to the one experiment and 5 control groups. Blood samples collected in each group at 30 and 60 days post-vaccination (DPV). Immune response was measured with virus neutralization test (VNT), liquid phase blocking ELISA (LPBE) for FMDV, VNT for BTV and PPR. A live virus challenge study was performed to determine the immune response of SGP vaccine. As a result, antibody titers for each vaccine agent decreased on 60 DPV with the simultaneous vaccination. The difference between means of antibody titers with single and simultaneous vaccinations are significant especially for BTV and PPR vaccines at 60DPV (p < 0.05). It was concluded that four vaccines can not be used simultaneously in sheep.

Chromosomes Stability and Growth Assessment of a Newly Established Lamb Heart Cell Line Sensitive to Lumpy Skin Disease Virus

“…Lumpy skin disease virus (LSDV) or the Neethling virus is classified in the genus Capri pox virus of the family Poxviridae. So, it is closely related to the sheep pox virus (SPPV) and goat pox virus (GTPV) (Sareyyüpoğlu et al, 2023). It is one of the highly emerging bovine threats due to its direct significance on the animal's productivity and Therefore, the presented study targeted the development of a stable lamb heart cell line and tested its sensitivity to LSDV.…”