Antibody Response to a Live-Modified Virus Vaccine against Bovine Viral Diarrhoea in Dairy Cattle in a Field Trial

Klimowicz-Bodys, Małgorzata D.; Płoneczka-Janeczko, Katarzyna; Czopowicz, Michał; Polak, M.P.; Lachowicz-Wolak, Agnieszka; Rypuła, Krzysztof

doi:10.3390/vaccines9030259

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…Another possibility is that a longer booster period would have increased titers. In another study, BVDV titers continued to increase for 2 months post-vaccination with an MLV vaccine ( 26 ), possibly indicating that the 56-day experimental period was not sufficient time to detect the peak neutralizing antibody titers in the MLV3 treatment group. However, the protective threshold titer level is unknown.…”

Section: Discussionmentioning

confidence: 99%

Immune phenotype is differentially affected by changing the type of bovine respiratory disease vaccine administered at revaccination in beef heifers

et al. 2023

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During preconditioning, modified-live vaccines are frequently administered to beef calves before weaning. In this study, we began to characterize the immune phenotype of calves that received a modified-live vaccination at 3–4 months of age and then either received the same modified-live or an inactivated vaccine upon arrival at the feedlot (weaning) and 28 days post-arrival (booster). Innate and adaptive immune measures were assessed before revaccination and 14 and 28 days post. Heifers that received three doses of the modified-live vaccine exhibited a relatively balanced immune response based on increases in mean cytokine concentrations (IL-17, IL-21) and total immunoglobulin-G (IgG) and subsets IgG1 and IgG2, which are related to both arms of the adaptive immune system. Conversely, heifers that received one dose of modified live and two doses of the inactivated vaccine had a more robust neutrophil chemotactic response and greater serum-neutralizing antibody titers, resulting in an enhanced innate immune and a skewed proinflammatory response. These results indicate that the revaccination protocol used after initial vaccination with a modified-live vaccine differentially influences the immune phenotype of beef calves, with three doses of modified live inducing potentially immune homeostasis and a combination of modified live and inactivated vaccines inducing a skewed immune phenotype. However, more research is needed to determine the protective efficacy of these vaccination protocols against disease.

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Section: Discussionmentioning

confidence: 99%

Immune phenotype is differentially affected by changing the type of bovine respiratory disease vaccine administered at revaccination in beef heifers

et al. 2023

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“…Samples with S/P ratio values ≥ 0.3 were classified as positive; those with values less than 0.2 were considered negative. Previous research has shown that, using the VNT as the reference standard, the ELISA manufacturer’s recommended cut-off was appropriate, with sensitivity and specificity of 96.7% and 97.1%, respectively [ 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

Bovine Viral Diarrhea Virus Antibody Level Variation in Newborn Calves after Vaccination of Late-Gestational Cows

Kim,

Kang,

Jang

et al. 2023

Veterinary Sciences

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This study was conducted to confirm variation in bovine viral diarrhea virus (BVDV) antibody levels transferred to calves from their mother’s colostrum after vaccination of late-gestational cows. Blood samples were drawn from 60 pregnant cows that had been vaccinated more than one year and less than two years previously. The samples were collected six weeks prior to the expected date of delivery. After sample collection, the cows were divided into two groups of 30. One group received 2 mL of BVDV vaccine, and a control group received 2 mL of phosphate-buffered saline (PBS). Blood was collected from the cows three weeks post-administration. Additional blood samples were taken from calves at 1, 4, 8, 12, 16, and 20 weeks after birth. The serum was separated from the collected blood, and BVDV antibody changes were confirmed by enzyme-linked immunosorbent assays. BVDV antibody levels were higher from 8 to 20 weeks of age in calves born to late-gestational BVDV-vaccinated cows than in calves born to control cows (p < 0.0083). Further analysis confirmed a slow decline in BVDV maternal antibodies in calves born to pregnant cows that produced high levels of BVDV antibodies following pre-calving BVDV vaccination. These results suggest that BVDV vaccination of cattle in late pregnancy may help to extend the duration of protection against BVDV infection in newborn calves.

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“…It was reported that vaccinates may continually increasing antibody titer response for up to 3 months post-vaccination against BVDV also that stress-induced immunosuppression can enhance the antibody titer responses to MLV vaccination. 18,19 For IBRV titers, there was a timing effect (P = 0.002) and a tendency for a timing × vaccine interaction (P = 0.06). The VIS0 treatment had the greatest percentage seropositive against IBRV, VIS28 was the least, and NAS0 and NAS28 were intermediate (60.7, 34.1, 37.0, and 43.7%, respectively).…”

Section: Serum Antibody Titersmentioning

confidence: 98%

Effects of intranasal or parenteral respiratory vaccination administered on-arrival or delayed in auction-derived feedlot heifers

McAllister,

Powledge,

Parks

et al. 2023

Bov. pract.

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The objective was to evaluate health, performance and serum antibody responses of auction-derived heifers to an intranasal or parenteral MLV administered on d 0 or 28. Three arrival blocks of heifers, initial BW = 459 lb ± 1.7 lb (208 kg ± 27kg; n = 600), were randomly assigned to treatments consisting of 15 pens/treatment with pen as the experimental unit and 10 heifers/pen. Treatments were: 1) Bovilis® Nasalgen® 3 and Bovilis® Vista® BVD on d 0 (NAS0); 2) Bovilis® Vista® 5 SQ on d 0 (VIS0); 3) Bovilis® Nasalgen® 3 and Bovilis® Vista® BVD on d 28 (NAS28); 4) Bovilis® Vista® 5 SQ on d 28 (VIS28). Body weight and blood samples were collected on d 0, 28 and 56. Activity (351.4 vs 354.3 min/d) and rumination time (282.6 vs 285.4 min/d) was less (P < 0.01) for delayed vs arrival vaccinated heifers. A timing χ vaccine χ day interaction existed (P < 0.01) for BRSV- and IBRV-specific antibody titers; VIS28 had the greatest (P < 0.01) BRSV antibody titer on d 56. For IBRV antibody titer on d 28, VIS0 was greatest, NAS0 was intermediate, and VIS28 and NAS28 were least (P < 0.01). Percentage of chronically ill heifers were reduced for arrival vs delayed (1.3 vs 4.7%; P = 0.02) and arrival vaccinated had a reduction in antimicrobial treatment cost ($4.63 vs $7.31; P = 0.02). Data indicate improvement in some health outcomes for the parenteral route and arrival timing of MLV, but performance was not affected.

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Antibody Response to a Live-Modified Virus Vaccine against Bovine Viral Diarrhoea in Dairy Cattle in a Field Trial

Cited by 7 publications

References 20 publications

Immune phenotype is differentially affected by changing the type of bovine respiratory disease vaccine administered at revaccination in beef heifers

Immune phenotype is differentially affected by changing the type of bovine respiratory disease vaccine administered at revaccination in beef heifers

Bovine Viral Diarrhea Virus Antibody Level Variation in Newborn Calves after Vaccination of Late-Gestational Cows

Effects of intranasal or parenteral respiratory vaccination administered on-arrival or delayed in auction-derived feedlot heifers

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