Antibody response to rabies virus in Syrian hamsters

Coe, John E.; Bell, Jessica K.

doi:10.1128/iai.16.3.915-919.1977

Cited by 9 publications

(2 citation statements)

References 10 publications

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“…Hooper et al (1998) demonstrated that in addition to VNA, inflammatory mechanisms also contribute to clearance of virus infection. Coe and Bell (1977) showed the presence of VNA in Syrian hamsters as early as day 5 post inoculation with RABV. However, clinical signs were observed from day 8 to 9 whilst death followed after 2-5 days of onset of symptoms.…”

Section: Introductionmentioning

confidence: 94%

“…Although VNA has been shown to be important in clearance of RABV infection (Hooper et al 1998), there are other mechanisms that also play a role in virus clearance (Hooper et al 1998). Therefore, the presence of VNA after challenge with a virus does not necessarily guarantee survival; this was also observed by Coe and Bell (1977) and Roy et al (2007).…”

Section: Serological Response Of Mice To Infection With African Lyssavirusesmentioning

confidence: 99%

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Comparison of pathogenic domains of rabies and African rabies-related lyssaviruses and pathogenicity observed in mice

Kgaladi

Nel

Markotter

2013

Onderstepoort J Vet Res

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Several lyssavirus species occur in Africa (Rabies virus, Lagos bat virus, Mokola virus, Duvenhage virus, Shimoni bat virus and Ikoma lyssavirus), displaying a high sequence diversity between isolates belonging to the same species. There is limited information about comparative pathogenesis of these African lyssaviruses and this precludes authoritative opinion on the potential public and veterinary health impact. In this study, an analysis of representative African lyssaviruses attempted to correlate viral genomic sequence similarities and differences with the corresponding pathogenic profiles observed in mice. The study demonstrated that the virus isolates evaluated could be lethal to mice when introduced intramuscularly and that different isolates of the same lyssavirus species differ in their virulence. Using real-time polymerase chain reaction (PCR), viral RNA was detected in brain tissue, but no viral RNA was detected in the salivary glands or blood of mice that succumbed to infection. Comparison of known pathogenic domains indicated that pathogenicity is likely to be dependent on multiple domains. Cumulatively, our results re-emphasised the realisation that the pathogenicity of a lyssavirus species cannot be deduced based on studies of only a single isolate of the species or a single pathogenic domain.

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Section: Introductionmentioning

confidence: 94%