Antibody responses elicited by mRNA vaccination in firefighters persist six months and correlate inversely with age and directly with BMI

Holtkamp, Caroline; Schöler, Lara; Anastasiou, Olympia E.; Brune, Bastian; Fessmann, Kai; Elsner, Carina; Möhlendick, Birte; Čiučiulkaitė, Ieva; Dudda, Marcel; Trilling, Mirko; Dittmer, Ulf; Spors, Jörg; Le‐Trilling, Vu Thuy Khanh

doi:10.1016/j.heliyon.2022.e12746

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Younger age was associated with a better humoral immune response after basic immunization in our study group. These results are in agreement with several other studies [ 10 , 13 , 14 , 15 , 46 , 48 , 49 ]. After the booster vaccination, the influence of sex and age on the humoral immune response considerably diminished in our study group.…”

Section: Discussionsupporting

confidence: 94%

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Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in IFITM3 on the Antibody Response after Vaccination against COVID-19

et al. 2023

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The COVID-19 mRNA vaccine is the first mRNA vaccine approved for human administration by both the U.S. Food and Drug Administration and the European Medicines Agency. Studies have shown that the immune response and the decay of immunity after vaccination with the COVID-19 vaccines are variable within a population. Host genetic factors probably contribute to this variability. In this study, we investigated the effect of the single-nucleotide polymorphisms rs12252 and rs34481144 in the interferon-induced transmembrane protein (IFITM) 3 gene on the humoral immune response after vaccination against COVID-19 with mRNA vaccines. Blood samples were collected from 1893 healthcare workers and medical students at multiple time points post-vaccination and antibody titers against the SARS-CoV-2 S1 protein receptor binding domain were determined at all time points. All participants were genotyped for the rs34481144 and rs12252 polymorphisms in the IFITM3 gene. After the second and third vaccinations, antibody titer levels increased at one month and decreased at six months (p < 0.0001) and were higher after the booster vaccination than after the basic immunization (p < 0.0001). Participants vaccinated with mRNA-1273 had a higher humoral immune response than participants vaccinated with BNT162b2. rs12252 had no effect on the antibody response. In contrast, carriers of the GG genotype in rs34481144 vaccinated with BNT162b2 had a lower humoral immune response compared to A allele carriers, which reached statistical significance on the day of the second vaccination (p = 0.03) and one month after the second vaccination (p = 0.04). Further studies on the influence of rs12252 and rs34481144 on the humoral immune response after vaccination against COVID-19 are needed.

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Section: Discussionsupporting

confidence: 94%

“…Regarding our results one month after the booster vaccination, the same pattern was observed by Holtkamp et al In this study, professional firefighters with a higher BMI had a better humoral immune response. Holtkamp et al speculated that a higher BMI does not necessarily reflect obesity and may be caused by higher muscle mass [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in IFITM3 on the Antibody Response after Vaccination against COVID-19

et al. 2023

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Impact of Immunosenescence on Vaccine Immune Responses and Countermeasures

Chen,

Shao,

et al. 2024

Vaccines

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The biological progression of aging encompasses complex physiological processes. As individuals grow older, their physiological functions gradually decline, including compromised immune responses, leading to immunosenescence. Immunosenescence significantly elevates disease susceptibility and severity in older populations while concurrently compromising vaccine-induced immune responses. This comprehensive review aims to elucidate the implications of immunosenescence for vaccine-induced immunity and facilitate the development of optimized vaccination strategies for geriatric populations, with specific focus on COVID-19, influenza, pneumococcal, herpes zoster, and respiratory syncytial virus (RSV) vaccines. This review further elucidates the relationship between immunosenescence and vaccine-induced immunity. This review presents a systematic evaluation of intervention strategies designed to enhance vaccine responses in older populations, encompassing adjuvant utilization, antigen doses, vaccination frequency modification, inflammatory response modulation, and lifestyle interventions, including physical activity and nutritional modifications. These strategies are explored for their potential to improve current vaccine efficacy and inform the development of next-generation vaccines for geriatric populations.

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Antibody responses elicited by mRNA vaccination in firefighters persist six months and correlate inversely with age and directly with BMI

Cited by 2 publications

References 19 publications

Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in IFITM3 on the Antibody Response after Vaccination against COVID-19

Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in IFITM3 on the Antibody Response after Vaccination against COVID-19

Impact of Immunosenescence on Vaccine Immune Responses and Countermeasures

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