Antibody responses to inactivated vaccines and natural infection in cattle using bovine viral diarrhoea virus ELISA kits: Assessment of potential to differentiate infected and vaccinated animals

Raue, R.; Harmeyer, Silke; Nanjiani, Ian

doi:10.1016/j.tvjl.2009.12.013

Cited by 36 publications

(35 citation statements)

References 18 publications

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“…These findings were confirmed in other studies (ALVAREZ et al, 2012;MAKOSCHEY et al, 2007;RAUE et al, 2010). According to previous studies, indirect ELISA was very good in the detection of BVDV antibodies after vaccination (RAUE et al, 2010). According to the manufacturer, the specificity and sensitivity of iELISA kit are 99.5% and 96.3% compared to VNT.…”

Section: Discussionsupporting

confidence: 82%

“…It has been reported that some, but not all, inactivated BVDV vaccines do not induce detectable antibodies against the NS3 (p80) protein (GRAHAM et al, 2003). These findings were confirmed in other studies (ALVAREZ et al, 2012;MAKOSCHEY et al, 2007;RAUE et al, 2010). According to previous studies, indirect ELISA was very good in the detection of BVDV antibodies after vaccination (RAUE et al, 2010).…”

Section: Discussionsupporting

confidence: 60%

“…All animals older than six months within the three herds were vaccinated with polyvalent inactivated BVDV vaccine (Cattle Master, Pfizer). Two herds (A and B) were vaccinated in 2008, 2009and 2010. Herd C was vaccinated in 2008and 2010.…”

Section: Methodsmentioning

confidence: 99%

“…Two herds (A and B) were vaccinated in 2008, 2009and 2010. Herd C was vaccinated in 2008and 2010. In each herd, all heifers and cows (all animals older than six months) were vaccinated at the same time.…”

Section: Methodsmentioning

confidence: 99%

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Modified schedule of vaccination with polyvalent bovine viral diarrhea virus inactivated vaccine in dairy herds - a field study

Bedeković¹,

Krešić²,

Lojkić³

et al. 2017

Vet. arhiv

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________________________________________________________________________________________ BEDEKOVIĆ, T., N. KREŠIĆ, I. LOJKIĆ, I. ŠIMIĆ, Ž. CVETNIĆ, J. MADIĆ:Modified schedule of vaccination with polyvalent bovine viral diarrhea virus inactivated vaccine in dairy herds -a field study. Vet. arhiv 87, 239-248, 2017. ABSTRACTIn order to reduce the cost of vaccination, three herds were vaccinated with polyvalent bovine viral diarrhea virus inactivated vaccine according to a modified schedule, and the specific antibody response was evaluated. In each herd only the cows and heifers were vaccinated with one dose of vaccine. Two herds (A and B) were vaccinated annually for three consecutive years. The third herd (C) was vaccinated twice with a two year interval. At the beginning of the study the herds consisted of 38, 22 and 15 animals respectively. Antibody response was evaluated three and nine months after vaccination with indirect ELISA, blocking ELISA and a virus neutralization test. Within herds A and B the percentage of seropositive animals increased with each subsequent vaccination. Three months after the third vaccination more than 96% of animals in herds A and B were seropositive. Nine months after the third vaccination more than 56% of animals in herds A and B were seropositive. Three and nine months after the second vaccination the numbers of positive animals in herd C was 66% and 38% respectively. The obtained results show that the percentage of seropositive animals within the herds increased with each vaccination and the best detection of specific antibodies after vaccination can be achieved if a virus neutralization test is used. Also, the results show that seroprotection of cows within the herds vaccinated yearly was significantly higher (56.52-58.82%) compared to the herd vaccinated with a two year interval (38.88%).

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 60%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Modified schedule of vaccination with polyvalent bovine viral diarrhea virus inactivated vaccine in dairy herds - a field study

Bedeković¹,

Krešić²,

Lojkić³

et al. 2017

Vet. arhiv

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“…The fact that we were able to detect MHC Ags within the antigenic fraction of the vaccine may be sufficient to prime an alloresponse in MHC-discordant recipients. Moreover, the adjuvant, by inducing a strong Ab response compared with that of other commercial vaccines against BVD virus (11,40), may favor the development of high titers of alloreactive Abs in some animals highly responsive to immunization. Because of the large variability of the MHC in mammals, the frequency of the alloresponders is expected to be relatively low, which fits with the low occurrence of the disease as reported by epidemiological studies.…”

Section: Discussionmentioning

confidence: 99%

Alloantibodies against MHC Class I: A Novel Mechanism of Neonatal Pancytopenia Linked to Vaccination

Foucras

Corbière

Tasca

et al. 2011

The Journal of Immunology

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Fetal/neonatal alloimmune thrombocytopenia is a frequent disease in humans where alloantibodies against platelet Ags lead to platelet destruction and hemorrhage. Although a role in the disease for Abs against MHC has been suspected, this has not been formally demonstrated. Since 2007, a hemorrhagic syndrome due to thrombocytopenia and designated as bovine neonatal pancytopenia (BNP) has been recognized in calves in several European countries. An inactivated antiviral vaccine is strongly suspected to be involved in this syndrome because of its highly frequent use in the dams of affected calves. In this study, we show that BNP is an alloimmune disease, as we reproduced the signs by transferring serum Abs from vaccinated BNP dams into healthy neonatal calves. Ab specificity was strongly associated with the presence of allogeneic MHC class I Abs in the dams. MHC class I staining was also observed on Madin–Darby bovine kidney cells, a cell line related to the one used to produce the vaccine Ag. Our report emphatically demonstrates that alloimmunization against MHC class I is associated with a substantial risk of developing cytopenia-associated syndromes in neonates when a cell line of the same species is used to produce an inactivated vaccine injected into the mother.

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Infectious Agents

Passler

2014

Bovine Reproduction

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Antibody responses to inactivated vaccines and natural infection in cattle using bovine viral diarrhoea virus ELISA kits: Assessment of potential to differentiate infected and vaccinated animals

Cited by 36 publications

References 18 publications

Modified schedule of vaccination with polyvalent bovine viral diarrhea virus inactivated vaccine in dairy herds - a field study

Modified schedule of vaccination with polyvalent bovine viral diarrhea virus inactivated vaccine in dairy herds - a field study

Alloantibodies against MHC Class I: A Novel Mechanism of Neonatal Pancytopenia Linked to Vaccination

Infectious Agents

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