Antibody studies in hypogammaglobulinemia.

Ching, Yi-Chuan; Davis, Starkey D.; Wedgwood, Ralph

doi:10.1172/jci105465

Cited by 32 publications

(14 citation statements)

References 26 publications

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“…Bacteriophage disappeared from the circulation of all volunteers and most patients by the 4th day. This finding is similar to that reported previously (7). The eight cases classified as infantile X-linked agammaglobulinemia in group I had prolonged circulation of bacteriophage (Fig.…”

Section: Resultssupporting

confidence: 91%

“…2. The K values shown are similar to those obtained in a previous study on six immunologically competent children (7). Highest K values were consistently reached 2 wk after immunization; titers then declined.…”

Section: Resultssupporting

confidence: 86%

“…It is a potent antigen and causes no recognized toxic effects in man (7). After intravenous administration, phage can be detected easily and enumerated in the blood by plaque count.…”

Section: New Namementioning

confidence: 99%

“…Neutralizing antibody. After phage had disappeared from the circulation, the antibody activity was determined by phage neutralization and was expressed as the rate of inactivation or K value as derived by a standard formula (7). The lower limit of sensitivity by the usual 1-hr incubation is a K value of 0.01.…”

Section: New Namementioning

confidence: 99%

“…Most patients with impaired humoral immunity appear to make feeble antibody responses, but relatively few patients have been studied systematically (2)(3)(4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Immunologic responses to bacteriophage ϕX 174 in immunodeficiency diseases

Ochs¹,

Davis²,

Wedgwood³

1971

J. Clin. Invest.

211

134

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 86%

“…It is a potent antigen and causes no recognized toxic effects in man (7). After intravenous administration, phage can be detected easily and enumerated in the blood by plaque count.…”

Section: New Namementioning

confidence: 99%

Section: New Namementioning

confidence: 99%

“…Most patients with impaired humoral immunity appear to make feeble antibody responses, but relatively few patients have been studied systematically (2)(3)(4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Immunologic responses to bacteriophage ϕX 174 in immunodeficiency diseases

Ochs¹,

Davis²,

Wedgwood³

1971

J. Clin. Invest.

211

134

View full text Add to dashboard Cite

Nodular Lymphoid Hyperplasia of the Small Intestine and Sarcoidosis

Davis¹

1970

Arch Intern Med

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The Congenital Agammaglobulinemias

Davis¹,

Ching²,

Schaller³

et al. 1967

Am J Dis Child

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THE FIRST type of agammaglobulinemia reported was an X-linked recessive disease characterized by recurrent bacterial infections, very low serum immunoglobulins,* and absence of antibody responses.1 Many other types have since been recog-nized2-5 and a short classification of the agammaglobulinemias is listed in Table 1. Each type appears to be distinct, and each is probably the result of a different defect in the maturation and function of immunologic mechanisms.The purpose of this report is to present studies of seven patients with agammaglobulinemia. These studies indicate that cases currently called congential sporadic agammaglobulinemia may be a heterogeneous group with different defects of immunity.Agammaglobulinemia is used here in the generic sense to mean a group of related diseases which are characterized by low serum immunoglobulins, impaired antibody response, and abnormal lymphoid morphology. The use of agammaglobulinemia in this sense is comparable to the use of anemia to indicate diseases of red blood cells. Report of CasesCase 1.-This 11-year-old girl is one of identical twins (case 2). She had recurrent colds and otitis media from early infancy. Lat¬ er she had uncomplicated primary vaccination, measles, and chickenpox. At one age of 3 years she began having recurrent episodes of pneu¬ monia which required hospitalization almost monthly. At age 6 she was found to have agam¬ maglobulinemia and was referred to University Hospital. She was of small stature and had chronic otitis media, pneumonia, and small cer¬ vical and inguinal lymph nodes. Cultures of the throat and sputum on subsequent visits often grew out Haemophilus influenza. Bronchograms at age 8 demonstrated bronchiectasis of the lingula and left lower lobe. X-ray films of the nasopharynx showed a decreased amount of lymphoid tissue.She was started on therapy with -globulin, postural drainage, and antibiotics as indi¬ cated. She continued to have recurrent pneu¬ monia and otitis media, and at age 8 underwent surgical resection of bronchiectatic portions of the left lung. Since then she has been treated with -globulin and several courses of continu¬ ous tetracyline therapy. She has improved but continues to have recurrent colds, otitis media,

show abstract

Antibody studies in hypogammaglobulinemia.

Cited by 32 publications

References 26 publications

Immunologic responses to bacteriophage ϕX 174 in immunodeficiency diseases

Immunologic responses to bacteriophage ϕX 174 in immunodeficiency diseases

Nodular Lymphoid Hyperplasia of the Small Intestine and Sarcoidosis

The Congenital Agammaglobulinemias

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