1980
DOI: 10.1111/j.1365-3024.1980.tb00052.x
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Antibody suppression in mice infected with Nippostrongylus brasiliensis

Abstract: A/SN mice infected with N. Brasiliensis showed depressed anti-DNP antibody responses following immunization with DNP-Asc in alum. The immunosuppression was only observed when infection preceded immunization by between 2 and 7 days, and was not achieved when the interval was extended to 10 days. The suppression lasted at least 50 days, and affected IgE levels more than IgG1 or IgG agglutinating anti-DNP antibodies. A high dose of infective larvae (500-1000 per mouse) was necessary to induce suppression. Use of … Show more

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Cited by 12 publications
(5 citation statements)
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“…Although a number of hypotheses have been proposed to explain how nematodes might survive in otherwise fully immunocompetent hosts, none of these are supported by convincing evidence of a functional significance for the parasites concerned. In common with some species of protozoa, parasitic helminths may cause non-specific immunodepression in the host (HAIG et al, 1980;FAUBERT & TANNER, 1971;ARAUJO et al, 1977;PORTARO et al, 1976), the precise significance of which is not understood, although it has been suggested that this may be a mechanism by which the organisms facilitate their own survival (OGILVIE & WILSON, 1976).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although a number of hypotheses have been proposed to explain how nematodes might survive in otherwise fully immunocompetent hosts, none of these are supported by convincing evidence of a functional significance for the parasites concerned. In common with some species of protozoa, parasitic helminths may cause non-specific immunodepression in the host (HAIG et al, 1980;FAUBERT & TANNER, 1971;ARAUJO et al, 1977;PORTARO et al, 1976), the precise significance of which is not understood, although it has been suggested that this may be a mechanism by which the organisms facilitate their own survival (OGILVIE & WILSON, 1976).…”
Section: Discussionmentioning
confidence: 99%
“…A particular problem in this respect is the observation that not only parasites which cause chronic infections, but also those which are effectively resisted by the host, may interfere with the host response to concurrently administered heterologous antigens (FAUBERT & TANNER, 1971;FAUBERT, 1977;HAIG et al, 1980). Furthermore there is evidence that parasite-induced immunodepression does not affect the host response to parasite antigens.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, whilst Nippostrongylus brasiliensis enhances anti-DNP and anti-ovalbumin (OA) responses in several hosts (e.g. Kojima & Ovary 1975, Allan & Mayrhofer 1981, it depresses responses to DNP-Asc in Al(OH)3 in A/Sn mice (Haig, Lima & Mota 1980). These contrasts highlight the need for systematic investigation of the roles of the host, the antigen and the timing of infection relative to fundamental differences between helminth species.…”
Section: Introductionmentioning
confidence: 99%
“…Os helmintos e alguns de seus produtos exercem importante efeito modulador no sistema imune (FAQUIM-MAURO;MACEDO, 1998;revisado por FINKELMAN et al, 1991;HAIG;LIMA;MOTA, 1980;SILVA et al, 2006). Neste contexto, nós temos estudado o mecanismo imunomodulador de antígenos de alta massa molecular do extrato de Asc (FAVORETTO et al, 2014).…”
Section: Discussionunclassified
“…Heligmosomoides polygyrus e Schistosoma mansoni, além de induzirem em seu hospedeiro resposta Th2 caracterizada pela alta produção de anticorpos IgE, secreção de IL-4 e IL-5, eosinofilia e mastocitose, também exercem potente efeito imunomodulador (revisado por FINKELMAN et al, 1991;HAIG et al, 1980;ISHIZAKA et al, 1969;ORR;BLAIR, 1969).…”
Section: Helmintos E O Sistema Imuneunclassified