Antibody titers against vaccine and contemporary wild poliovirus type 1 in children immunized with IPV + OPV and young adults immunized with OPV

Lukashev, Alexander N.; Yarmolskaya, Maria S.; Shumilina, Elena; Сычев, Д А; Kozlovskaya, Liubov I.

doi:10.1016/j.virusres.2015.11.025

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…This virus differed from the corresponding Sabin strain by over 17% nucleotide sequence of VP1. Taking into account that poliovirus accumulates about 1% substitutions in VP1 per year [19], it is most likely that this virus was excreted by an immunodeficient vaccine recipient (or a contact of an OPV recipient), since such a long-term circulation of VDPV in a highly immunized population [25] is unlikely, although it cannot be completely excluded. It is noteworthy that a targeted search for persisting polioviruses in immunocompromised children, which are a risk group for preserving divergent viruses, was carried out in Russia, including Moscow, in 2008–2013 (136 enrolled patients) [26] and in 2014–2015 (83 enrolled patients) [27].…”

Section: Discussionmentioning

confidence: 99%

Environmental Surveillance for Poliovirus and Other Enteroviruses: Long-Term Experience in Moscow, Russian Federation, 2004–2017

Ivanova

Yarmolskaya

Eremeeva

et al. 2019

Viruses

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Polio and enterovirus surveillance may include a number of approaches, including incidence-based observation, a sentinel physician system, environmental monitoring and acute flaccid paralysis (AFP) surveillance. The relative value of these methods is widely debated. Here we summarized the results of 14 years of environmental surveillance at four sewage treatment plants of various capacities in Moscow, Russia. A total of 5450 samples were screened, yielding 1089 (20.0%) positive samples. There were 1168 viruses isolated including types 1–3 polioviruses (43%) and 29 different types of non-polio enteroviruses (51%). Despite using the same methodology, a significant variation in detection rates was observed between the treatment plants and within the same facility over time. The number of poliovirus isolates obtained from sewage was roughly 60 times higher than from AFP surveillance over the same time frame. All except one poliovirus isolate were Sabin-like polioviruses. The one isolate was vaccine-derived poliovirus type 2 with 17.6% difference from the corresponding Sabin strain, suggesting long-term circulation outside the scope of the surveillance. For some non-polio enterovirus types (e.g., Echovirus 6) there was a good correlation between detection in sewage and incidence of clinical cases in a given year, while other types (e.g., Echovirus 30) could cause large outbreaks and be almost absent in sewage samples. Therefore, sewage monitoring can be an important part of enterovirus surveillance, but cannot substitute other approaches.

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Section: Discussionmentioning

confidence: 99%

Environmental Surveillance for Poliovirus and Other Enteroviruses: Long-Term Experience in Moscow, Russian Federation, 2004–2017

Ivanova

Yarmolskaya

Eremeeva

et al. 2019

Viruses

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“…In 2010, a poliomyelitis outbreak was caused by a wild PV1 in Congo with a unique and consequential mutation signature (PV1-RC2010), resulting in 445 deaths with 47% mortality [30]. Later serological studies reported that 15-29% of individuals vaccinated with IPVs in Germany and 15-50% of individuals vaccinated with OPVs and/or IPVs in Russia were seronegative against this PV1-RC2010 strain, though 100% of them in Germany and 92-96% of them in Russia were seropositive against Sabin or wild PV1 vaccine strains [31,32]. Further, a smaller scale serological study in the US tested a panel of wild and vaccine-derived PV1 against 26 sera from vaccine-immunized healthy individuals: despite a significant reduction in nAb against PV1 strains that were immunologically different from the vaccine strain, especially with only 54% seropositive rate against PV1-RC2010, administration of a booster dose of IPV restored nAb against all strains [33].…”

Section: Discussionmentioning

confidence: 99%

Immuno-persistence after the 4th and 5th dose of inactivated polio vaccines in school-aged children

Leung,

Pang,

et al. 2024

Preprint

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Despite decades of research, questions remain about the persistence of neutralising antibodies (nAb) and serological correlates of polio vaccine efficacy. In a cross-sectional study among 299 children in Hong Kong, we estimated that the mean nAb titres against polioviruses type 1, 2 and 3 (PV1, PV2 and PV3) one month after receiving the 4th dose of inactivated polio vaccine (IPV) at 19 months of age were 2,068 (95% credible interval: 1,517 – 2,864), 4,705 (3,439 – 6,436) and 2,758 (1,894 – 4,086), but declined substantially in 4 years to 268 (222 – 325), 751 (630 – 900), and 411 (323 – 521), respectively. Administration of the 5th dose of IPV restored nAb titres among children aged 6-7 years, and the decline in nAb titres was slightly slower with the estimated mean titres of 355 (272 – 462), 538 (427 – 681), and 548 (378 – 786) against PV1, PV2, and PV3 at 4 years post the 5th dose. We estimated that the proportion of children who were seroprotected against PV1, PV2 and PV3 would drop below 90% at: (i) 8.2, 10.8, 8.7 years after the 4th dose; and (ii) 11.6, 11.2, 11.0 years after the 5th dose, highlighting the importance of maintaining populational immune persistence at high nAb levels.

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Suboptimal Serologic Immunity Against Poliomyelitis Among New Migrant Children in Greece Calls for Organized Action

Ioannidou

Galanis

Voulgari-Kokota

et al. 2022

J Immigrant Minority Health

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Antibody titers against vaccine and contemporary wild poliovirus type 1 in children immunized with IPV + OPV and young adults immunized with OPV

Cited by 4 publications

References 4 publications

Environmental Surveillance for Poliovirus and Other Enteroviruses: Long-Term Experience in Moscow, Russian Federation, 2004–2017

Environmental Surveillance for Poliovirus and Other Enteroviruses: Long-Term Experience in Moscow, Russian Federation, 2004–2017

Immuno-persistence after the 4th and 5th dose of inactivated polio vaccines in school-aged children

Suboptimal Serologic Immunity Against Poliomyelitis Among New Migrant Children in Greece Calls for Organized Action

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