Antibody to mouse alpha/beta interferon abrogates Pichinde virus-induced liver lesions in suckling mice

Clark, Theodore G.; Pfau, C. J.; Moss, Jill; Woodrow, David

doi:10.1128/jvi.59.3.728-730.1986

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Strikingly, however, prior inoculation with anti-interferon IgG inhibited the early manifestations of LCMV disease [26], as well as the later development of glomerulonephritis [27]. Furthermore, the same antibody abrogated the liver necrosis of Pichinde virus (another arenavirus) infected suckling mice [28]. It should be noted that, as first described in 1971 [29], in most instances, antibody to interferon exacerbates the manifestations of acute viral disease.…”

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confidence: 82%

A Brief Historical Perspective on the Pathological Consequences of Excessive Type I Interferon Exposure In vivo

2018

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confidence: 82%

A Brief Historical Perspective on the Pathological Consequences of Excessive Type I Interferon Exposure In vivo

2018

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“…While the host tropism of PICV has not been fully determined, the virus has been shown to infect both guinea pigs and mice as well as cells from several other species, including African green monkey (Vero) ( 30 ), hamster (BHK-21) ( 30 ) and human (PBMCs and THP1) ( 31 ). While the tissue tropism within mice and guinea pigs can be quite diverse, infectious virus and pathology mediated by virus infection can be found systemically in guinea pigs ( 25 ) and suckling mice ( 32 , 33 ).…”

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confidence: 99%

RIG-I and MDA5 Protect Mice From Pichinde Virus Infection by Controlling Viral Replication and Regulating Immune Responses to the Infection

et al. 2021

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RIG-I and MDA5 are major cytoplasmic innate-immune sensor proteins that recognize aberrant double-stranded RNAs generated during virus infection to activate type 1 interferon (IFN-I) and IFN-stimulated gene (ISG) expressions to control virus infection. The roles of RIG-I and MDA5 in controlling replication of Pichinde virus (PICV), a mammarenavirus, in mice have not been examined. Here, we showed that MDA5 single knockout (SKO) and RIG-I/MDA5 double knockout (DKO) mice are highly susceptible to PICV infection as evidenced by their significant reduction in body weights during the course of the infection, validating the important roles of these innate-immune sensor proteins in controlling PICV infection. Compared to the wildtype mice, SKO and DKO mice infected with PICV had significantly higher virus titers and lower IFN-I expressions early in the infection but appeared to exhibit a late and heightened level of adaptive immune responses to clear the infection. When a recombinant rPICV mutant virus (rPICV-NPmut) that lacks the ability to suppress IFN-I was used to infect mice, as expected, there were heightened levels of IFN-I and ISG expressions in the wild-type mice, whereas infected SKO and DKO mice showed delayed mouse growth kinetics and relatively low, delayed, and transient levels of innate and adaptive immune responses to this viral infection. Taken together, our data suggest that PICV infection triggers activation of immune sensors that include but might not be necessarily limited to RIG-I and MDA5 to stimulate effective innate and adaptive immune responses to control virus infection in mice.

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Partially purified leaf extracts of Melia azedarach L. inhibit tacaribe virus growth in neonatal mice

Coulombié¹,

Andrei²,

Laguens

et al. 1992

Phytotherapy Research

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Neonatal mice, inoculated intraperitoneally with lo3 PFU of Tacaribe virus, died after developing a typical encephalitis. The administration of partially purified extracts of Melia azedarach L. (Ma) fresh green leaves, in seven doses by the same route, reduced virus spread which normally involves the kidneys, liver and brain. Mortality feu to 50% in treated mice and viral titres in brain were at least 3 logs lower than those of untreated mice. Surviving mice mounted a humoral immune response. High levels of neutralizing antibodies were present up to 60 days post-infection when the animals were killed. Ma administration exerts a marked decrease in circulating interferon levels of infected mice. Thus, at day 6 post-infection the amount of acid resistant interferon in treated animals was eight times lower than in those untreated.The antiviral effect of Ma in uiuo is clearly stated in this murine-arenavirus model.

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Antibody to mouse alpha/beta interferon abrogates Pichinde virus-induced liver lesions in suckling mice

Cited by 3 publications

References 15 publications

A Brief Historical Perspective on the Pathological Consequences of Excessive Type I Interferon Exposure In vivo

A Brief Historical Perspective on the Pathological Consequences of Excessive Type I Interferon Exposure In vivo

RIG-I and MDA5 Protect Mice From Pichinde Virus Infection by Controlling Viral Replication and Regulating Immune Responses to the Infection

Partially purified leaf extracts of Melia azedarach L. inhibit tacaribe virus growth in neonatal mice

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