Antibody to Rhinovirus in Human Sera. II. Heterotypic Responses

Wf, Fleet; Rg, Douglas; Tr, Cate; Rb, Couch

doi:10.3181/00379727-127-32725

Cited by 20 publications

(6 citation statements)

References 2 publications

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“…However, insufficient antigenic stimulus may be the reason for this, particularly since recent reports (FAwzY et al, 1967;FLEET et al, 1968) have confirmed an earlier isolated observation (HA~PARIA~ et al, 1964) that heterologous antibody responses do occur in humans after natural and induced rhinovirus infections. Titres of our rhinovirus vaccines before inactivation were 105--106 TCDs0/ml which are 10-to 100-fold lower than minimum pre-inactivation titres of poliovirus (Salk type) vaccines.…”

mentioning

confidence: 61%

Absence of heterologous antibody responses in human volunteers after rhinovirus vaccination

Stott

Draper

Stones

et al. 1969

Archiv f Virusforschung

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Early reports of low level cross-neutralization reactions among the rhinoviruses (HAlving, CON~LLu and P~OCXNOW, 1964; HA~XPAl~IA~ et al., 1964) have been confirmed and expanded by F~NTERS and colleagues (1966) who found low level hcterologous responses in cattle immunised with rhinoviruses. They also showed that injection of previously immunised cattle and guinea pigs with heterologous related rhinoviruses induced anamnestie responses. In view of the possible applications to rhinovirus vaccines in man we investigated the heterologous responses induced in man by vaccines made from three different rhinoviruses which induce heterologous responses in animals: rhinovirus 2 which induced antibody in cattle against rhinoviruses 4, 33 and 34; rhinovirus 34 which induced heterologous antibody against rhinovirus 4 and some cross-reaction with rhinovirus 14; rhinovirus 35 which induced heterologous antibody against rhinoviruses 3, 4 and 14 (Fs, NT~aS et al,, 1966; ttAMaE, personal communication).Rhinovirus 2 vaccines were prepared either as live vaccine from PK strain grown in human embryo kidney cells or as formalin-inactivated vaccine from ttGP strain grown in monkey kidney cells. These vaccines were administered and sera collected as previously described (Scientific Committee on Common Cold Vaccines, 1965).Rhinovirus types 34 and 35 vaccines were grown in WI-38 cells and inactivated with formalin. Volunteers received two intramuscular injections of 1 ml of these vaccines at about monthly intervals. Sera were collected at each injection and one month after the final injection. Sera were titrated

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confidence: 61%

Absence of heterologous antibody responses in human volunteers after rhinovirus vaccination

Stott

Draper

Stones

et al. 1969

Archiv f Virusforschung

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“…Strains of RV 51 isolated in different years were shown to have antigenic variation (16). Several reports in the literature suggest that human beings show heterotypic antibody response after natural infection with rhinovirus (7,9,10).…”

Section: Resultsmentioning

confidence: 99%

Cross Relationships Among 37 Rhinoviruses Demonstrated by Virus Neutralization with Potent Monotypic Rabbit Antisera

et al. 1973

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Antisera produced in rabbits to 37 rhinovirus (RV) types have been examined for antibody to the 36 corresponding heterologous types. Reciprocal neutralization was noted between RV types 2 and 49 and RV types 13 and 41. Five additional monotypic rhinoviral rabbit antisera neutralized one heterologous rhinovirus. Neutralizing antibody titers against heterologous RV serotypes were similar to those shown in the RV 1A, 1B and RV 9, 32 reciprocal cross-reactions, and would not be expected to result in false identification of serotypes. Comparison of neutralizing antibody titers and neutralization rate constants in serial serum specimens of immunized rabbits showed that antibody response to the immunizing RV type and the cross-reacting type followed a similar time pattern.

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“…After treatment at 50 ° C, the virion RNA of HRV-2 may reside partly in a structure resistant to ribonuclease (30) ; at 56 ° C, HRV-2 is converted almost entirely to empty eapsids (B-particles) and RNA (73, 76) (see Fig. Production of heterotypie neutralizing antibodies are also detected in humans following infection with a single serotype of rhinovirus (35). Over 100 serotypes of human rhinoviruses have been identified by antibody neutralization (20,129).…”

Section: The Structure Of the Virionmentioning

confidence: 99%