2014
DOI: 10.5155/eurjchem.5.3.410-414.996
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Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes

Abstract: KEYWORDSTwo metal complexes of Ti(IV) were synthesized with newly prepared biologically active ligands. These ligands and their functional groups were carefully designed and selected from well known anticancer drugs. The ligands were prepared by the condensation of a mixture of sulfamethoxazole and the appropriate aldehyde namely, 3,4-dimethoxybenzaldehyde and 3,4,5-trimethoxybenzaldehyde. The structure of the ligands and their complexes were confirmed by spectroscopic data i.e. IR, 1 H NMR, electronic and ele… Show more

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Cited by 5 publications
(3 citation statements)
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“…Many Schiff base compounds have been reported to show high response when tested for in vitro and in vivo biological activities [5][6][7]. The wide range of pharmacological profiles exhibited by Schiff bases includes anticancer activity [6,[8][9][10][11][12], anticonvulsant [13], analgesic, and anti-inflammatory activities [14]. Cancer is caused by an abnormal and uncoordinated growth of a mass of tissue, which continues to multiply after cessation of the stimuli which initiated it [15].…”
Section: Introductionmentioning
confidence: 99%
“…Many Schiff base compounds have been reported to show high response when tested for in vitro and in vivo biological activities [5][6][7]. The wide range of pharmacological profiles exhibited by Schiff bases includes anticancer activity [6,[8][9][10][11][12], anticonvulsant [13], analgesic, and anti-inflammatory activities [14]. Cancer is caused by an abnormal and uncoordinated growth of a mass of tissue, which continues to multiply after cessation of the stimuli which initiated it [15].…”
Section: Introductionmentioning
confidence: 99%
“…Many coordination compounds of biologically active ligands have been synthesized and received much attention [1][2][3] . Chelation causes drastic change in the biological properties same applies to ligands and metal moieties 4 . Azomethines exhibit a wide range of pharmacological activities like antimicrobial 5 , anti-parasitic 6 , anti-inflammatory 7 and anticancer 8 .…”
Section: Introductionmentioning
confidence: 99%
“…Chelation causes drastic change in the biological properties or the ligands and also the metal moieties [4]. Azomethines exhibit a wide range of pharmacological activities like antimicrobial [5], anti-parasitic [6], anti-inflammatory [7] and anticancer [8].…”
Section: Introductionmentioning
confidence: 99%