Anticancer Activities of Hesperidin and Hesperetin In vivo and their Potentiality against Bladder Cancer

Stanisić, Danijela; Costa, Ana Rosa; Fávaro, Wagner José; Tasić, Ljubica; Seabra, Amedea B.

doi:10.4172/2157-7439.1000515

Cited by 25 publications

(15 citation statements)

References 53 publications

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“…126 Hesperidin and hesperetin have shown promising results in the suppression of various types of cancer (colon, prostate, hepatic, bladder, and lung cancer), as either a drug or as a pro-drug and co-adjuvant. 127 It has been extensively reported that hesperetin exerts neuroprotective effects in experimental models of neurodegenerative diseases. 128 Hesperetin displays marked inhibitory activity against replication of several diverse viruses.…”

Section: Pharmacological Significance Of Hesperidin and Hesperetinmentioning

confidence: 99%

Pharmacological Significance of Hesperidin and Hesperetin, Two Citrus Flavonoids, as Promising Antiviral Compounds for Prophylaxis Against and Combating COVID-19

Agrawal¹,

Agrawal²,

Blunden

2021

Natural Product Communications

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Hesperidin and hesperetin are flavonoids that are abundantly present as constituents of citrus fruits. These compounds have attracted attention as several computational methods, mostly docking studies, have shown that hesperidin may bind to multiple regions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (spike protein, angiotensin-converting enzyme 2, and proteases). Hesperidin has a low binding energy, both with the SARS-CoV-2 “spike” protein responsible for internalization, and also with the “PLpro” and “Mpro” responsible for transforming the early proteins of the virus into the complex responsible for viral replication. This suggests that these flavonoids could act as prophylactic agents by blocking several mechanisms of viral infection and replication, and thus helping the host cell to resist viral attack.

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Section: Pharmacological Significance Of Hesperidin and Hesperetinmentioning

confidence: 99%

Pharmacological Significance of Hesperidin and Hesperetin, Two Citrus Flavonoids, as Promising Antiviral Compounds for Prophylaxis Against and Combating COVID-19

Agrawal¹,

Agrawal²,

Blunden

2021

Natural Product Communications

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“…In the same manner, Ferreira de Oliveira and coauthors (2020) found out a that hesperidin was able to inhibit cell cycle transition in HeLa cells and also induce intracellular oxidation [47]. Consonantly, Stanisic and coauthors (2018) observed hesperidin capacity to increase by three times the calcium concentration in the cytoplasm of HeLa cells, promoting mitochondrial dysfunction that leads to apoptosis [48].…”

Section: Cytotoxicity Assaymentioning

confidence: 90%

Optimized Chitosan-Coated Gliadin Nanoparticles Improved the Hesperidin Cytotoxicity over Tumor Cells

Filho

Machado

Diedrich

et al. 2021

Braz. arch. biol. technol.

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Hesperidin is a natural compound which is found in citric fruits and presents antitumor and antimicrobial activities. However, the in vivo efficacy of Hesperidin is reduced due to its low oral bioavailability. Protein-based nanoparticles have been applied to improve biological parameters of drugs and natural compounds. Gliadin is a monomeric protein present in wheat. In this study, gliadin-based nanoparticles containing hesperidin were obtained by desolvation technique and a Taguchi orthogonal array design was employed to optimize the formulation. The independent variables were set as concentration of CaCl2 (0.5; 1 or 2%) and stabilizing agent (Pluronic F68, Tween 80 or sodium caseinate). The dependent variables consisted of mean diameter, polydispersity index, zeta potential, and encapsulation efficiency. The results showed significant effects on the dependent variables when 1% CaCl2 and Pluronic F68 were used. The optimized formulation was coated with chitosan to increase the physical stability of the nanoparticles. The final nanoparticles presented a mean diameter of 321 nm and polydispersity index of 0.217, and spherical shape. After coating, the Zeta potential was +21 mV, and the encapsulation efficiency was 73 %. The in vitro release assay showed that about 98% of the drug was released from the nanoparticles after 48 h. Moreover, HIGHLIGHTS A Taguchi design optimized the development of hesperidin-loaded gliadin nanoparticles. A chitosan-coating was added to improve the physical stability of nanoparticles. Nanoparticles reduced the hesperidin cytotoxicity over healthy Vero cells. Nanoparticles improved the hesperidin cytotoxicity over tumor cells.

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“…38 The RP11-119F7.4 gene, located on chromosome 10, acts as an antisense lncRNA, whose expression is downregulated in gastric cancer. 39 Hesperidin reportedly inhibited cell proliferation and induced apoptosis in human Burkitt's lymphoma Ramos, 40 HeLa cells, 41 breast cancer, 42 bladder cancer, 43 acute kidney injury, 44 and Parkinsonism. 45 Hesperidin induces human HepG2 cell apoptosis via the mitochondrial pathway and the death receptor pathway 46 and Wnt signaling.…”

Section: Discussionmentioning

confidence: 99%

Hesperidin suppressed hepatic precancerous lesions via modulation of exophagy in rats

Hasanin

Matboli

Seleem

2019

J of Cellular Biochemistry

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The enormous cost of modern medicines warrants alternative strategies for the better management of hepatocellular carcinoma. Recently, exosomes have been shown to relay the oncogenic information through the horizontal transfer of RNAs between the cells. In this study, we modulated exosomal production and autophagy (exophagy) by the administration of hesperidin and evaluated its effect on the development of hepatic precancerous lesion (HPC) in rats. Diethylnitrosamine and 2‐acetylaminofluorene were used in vivo to induce HPC in rats. Rats were allocated into five groups: naïve, HPC, and three hesperidin treated (50, 100, and 200 mg/kg/d; orally) for 4 consecutive days per week for 16 weeks. Liver tissues and blood samples were collected for histopathological, immunohistochemical, and transmission electron microscope examinations, liver function, alfa‐fetoprotein level, and isolation of exosomal and autophagy RNAs. Hesperidin administration showed hepato‐protective effects and improved the microscopic hepatic features with a decrease in glutathione S‐transferase placental precancerous foci and the abundance of exosomes in liver tissues. Hesperidin improved liver function with a significant decrease in alfa‐fetoprotein levels. Hesperidin dose‐dependently decreased exosomal RAB11A messsenger RNA and long noncoding RNA‐RP11‐583F2.2 along with the increase in exosomal miR‐1298, involved in the exophagy process. In conclusion, hesperidin likely suppresses liver carcinogenesis in rat model via the modulation of exosomal secretion and autophagy.

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Anticancer Activities of Hesperidin and Hesperetin In vivo and their Potentiality against Bladder Cancer

Cited by 25 publications

References 53 publications

Pharmacological Significance of Hesperidin and Hesperetin, Two Citrus Flavonoids, as Promising Antiviral Compounds for Prophylaxis Against and Combating COVID-19

Pharmacological Significance of Hesperidin and Hesperetin, Two Citrus Flavonoids, as Promising Antiviral Compounds for Prophylaxis Against and Combating COVID-19

Optimized Chitosan-Coated Gliadin Nanoparticles Improved the Hesperidin Cytotoxicity over Tumor Cells

Hesperidin suppressed hepatic precancerous lesions via modulation of exophagy in rats

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