Anticancer activities of novel chalcone and bis-chalcone derivatives

Preheated Fly-Ash Catalyzed Aldol Condensation: Efficient Synthesis of Chalcones and Antimicrobial Activities of Some 3-Thienyl Chalcones

“…Chalcones possess a wide range of biological activities such as antibacterial 32 , antifungal 32 , antiviral 33 , antifeedant 3,29 , anticancer 34 , antimalarial 35 , antituberclosis 28 , antiAIDS 36 and antioxidant 37 activities. These multipronged activities present in different chalcones are examined against respective microbes-bacteria's and fungi.…”

Chemical synthesis, docking studies and biological effects of functionalized 1,3-diaryl-2-propen-1-ones on human colon cancer cells

“…Chal-cones (1, 3-diaryl-2-propen-1-ones), constituting an enone system between two aromatic rings are an important class of natural products which are considered as precursors for various flavonoids and exhibit interesting pharmacological activities (Stu et al, 1971). Chalcones, originating from natural and synthetic routes possess several biological activities, such as cytotoxic (Modzelewska et al, 2006) anti-malarial (Dominguez et al, 2005), antileishmanial (Boeck et al, 2006) anti-inflammatory (Yang et al, 2007), anti-HIV (Cheenpracha et al, 2006), antifungal (Svetaz et al, 2004) and as tyrosine kinase inhibitors (Neryr et al, 2004). Because of very high pharmacological interest, these molecules have attracted medicinal chemists to design and synthesize further large number of chalcones with different functional groups.…”

Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones

“…They serve as precursors for the synthesis of different classes of flavonoids, which are common substances in plants. They have been reported to be the major bioactive constituents of medicinal herbs because of their anti-inflammatory, antioxidant (Cheng et al, 2008), antibacterial (Avila et al, 2008), antifungal (Sortino et al, 2007), and anticarcinogenic activities (Modzelewska et al, 2006;Kumar et al, 2003). These activities are largely attributed to the α,β-unsaturated ketone moiety (Rao et al, 2009).…”

“…These activities are largely attributed to the α,β-unsaturated ketone moiety (Rao et al, 2009). Their beneficial effects on health, and particularly the anticarcinogenic potential, have been credited to their inhibitory efficiency demonstrated in bacterial and mutagenicity tests (Avila et al, 2008;Modzelewska et al, 2006), chemopreventive activity against research artIcle Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones 1552 H. Aryapour et al…”