Anticancer activity, DNA binding and docking study of M(ii)-complexes (M = Zn, Cu and Ni) derived from a new pyrazine–thiazole ligand: synthesis, structure and DFT

Abstract

A series of structurally related Zn(II), Cu(II) and Ni(II) complexes of 4-(2-(2-(1-(pyrazin-2-yl)ethylidene)hydrazinyl)-thiazol-4-yl)-benzonitrile (PyztbH) have been synthesized and characterized by spectroscopy, single X-ray crystallography and density functional theory (DFT). All the...

Zn(ii) complexes with thiazolyl–hydrazones: structure, intermolecular interactions, photophysical properties, computational study and anticancer activity

“…67 To the best of our knowledge, only two publications address the anticancer properties of discrete zinc complexes with THs. 9,68 In this work, the antiproliferative activity of 1-3-NO 3 and 1-2-Cl was evaluated in vitro against six human cancer cell lines: A549, SW1573, HeLa, HBL-100, WiDr, and T-47D using the SRB colorimetric assay. The antiproliferative activity of 3-Cl was not evaluated because of its low solubility under the assay protocol.…”

“…These values are in the range of a similar Zn(II) pentacoordinated complex. 9 In the five remaining structures, two neutral tridentate ligand molecules coordinate the central Zn(II) ion, where the excess charge is neutralized by the anions present within the lattice (ZnCl 4 2− or NO 3…”

“…Preparation of pyridine-and pyrazine-based complexes enhanced ligands' antimicrobial and anticancer activities, while several of them even induced apoptosis. [5][6][7][8][9][10][11] On the other hand, THs and their complexes with Zn and Cd have shown photoluminescence properties. 12 Also, thiazolebased ligands [13][14][15][16] and their complexes with various metals, [17][18][19][20][21] including Zn, 22 showed promising photoluminescence properties.…”

“…23,24 In this work, we used N,N,N tridentate pyridine-based THs (HLS 1-3 , Scheme 2), 6,8 to prepare Zn(II) complexes starting from ZnCl 2 and Zn(NO 3 ) 2 . N,N,N Tridentate coordination to various metal ions is characteristic of this class of ligands, [5][6][7][8][9][10] as it is for the structurally similar pyrazine-based TH. 11 Since ligands HLS 1-3 , 4 and their complexes with Co(III) 6 and Cd(II) 7 were shown to possess significant antiproliferative activity, we investigated whether the coordination to Zn(II) may enhance the activity.…”

Recent advances in bacterial cellulose: a low-cost effective production media, optimization strategies and applications

“…Controlling and optimizing the production conditions and media also improves the yield and reduces production costs (Rahman et al 2021). The one-variable at a time (OVAT) approach is the most applied strategy for BC production optimization (Alemam et al 2021;Bera et al 2021). Due to the intensive labor and high cost involved in this strategy, more attention, in recent times, has been directed toward the implementation of statistical numerical designs as a more reliable and cost-effective alternative for BC production optimization (Bagewadi et al 2020;Singh et al 2017).…”