Anticancer activity of 28-Oxoallobetulin on HT-29 human colon cancer cells

Lee, Jeung-Min; Koo, Dahee; Park, Hae-Ryong

doi:10.1007/s10068-014-0181-6

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…[25][26][27][28][29] Other fruit ingredients (guava, passion fruit, noni and pineapple) have also been found effective for different cancer inhibition. [30][31][32][33] Therefore, to balance the possible side-effects and enhance the therapeutic efficacy of each component, we designated the vegetables (V), mulberry (M), fruits and spelt wheat (W) juice with fucoidan complex as an integrative functional beverage called VMW-FC.…”

Section: Discussionmentioning

confidence: 99%

Anti-Colorectal Cancer Effects of Fucoidan Complex-Based Functional Beverage Through Retarding Proliferation, Cell Cycle and Epithelial–Mesenchymal Transition Signaling Pathways

Chan,

Deng,

Peng

et al. 2023

Integr Cancer Ther

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Background: Fucus vesiculosus-derived fucoidan, a multifunctional bioactive polysaccharide sourced from marine organisms, exhibits a wide range of therapeutic properties, including its anti-tumor effects. While previous research has reported on its anti-cancer potential, limited studies have explored its synergistic capabilities when combined with other natural bioactive ingredients. In this current study, we present the development of an integrative functional beverage, denoted as VMW-FC, which is composed of a fucoidan complex (FC) along with a blend of various herbal components, including vegetables (V), mulberries and fruits (M), and spelt wheat (W). Objective: Colorectal cancer (CRC) remains a significant cause of mortality, particularly in metastatic cases. Therefore, the urgent need for novel alternative medicines that comprehensively inhibit CRC persists. In this investigation, we assess the impact of VMW-FC on CRC cell proliferation, cell cycle dynamics, metastasis, in vivo tumorigenesis, and potential side effects. Methods: Cell growth was assessed using MTT and colony formation assays, while metastatic potential was evaluated through wound healing and transwell migration assays. The underlying signaling mechanisms were elucidated through qPCR and western blot analysis. In vivo tumor formation and potential side effects were evaluated using a subcutaneous tumor-bearing NOD/SCID mouse model. Results: Our findings demonstrate that VMW-FC significantly impedes CRC proliferation and migration in a dose- and time-dependent manner. Furthermore, it induces sub-G1 cell cycle arrest and an increase in apoptotic cell populations, as confirmed through flow-cytometric analysis. Notably, VMW-FC also suppresses xenograft tumor growth in NOD/SCID mice without causing renal or hepatic toxicity. Conclusion: The integrative herbal concoction VMW-FC presents a promising approach for inhibiting CRC by slowing proliferation and migration, inducing cell cycle arrest and apoptosis, and suppressing markers associated with proliferation (Ki-67, PCNA, and CDKs) and epithelial-mesenchymal transition (EMT) (Vimentin, N-cadherin, and β-catenin).

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Section: Discussionmentioning

confidence: 99%

Anti-Colorectal Cancer Effects of Fucoidan Complex-Based Functional Beverage Through Retarding Proliferation, Cell Cycle and Epithelial–Mesenchymal Transition Signaling Pathways

Chan,

Deng,

Peng

et al. 2023

Integr Cancer Ther

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“…The quercetin-glycosides insulated from the flower cub of T. farfara shows the loftiest antioxidant exertion 112 . Lee et al 113 reported the (TF) -convinced cytotoxic and apoptotic conditioning of the flower part ofT. farfara in mortal colon cancer cell line( HT-29) by using a methanolic excerpt.…”

Section: Scutellaria Baicalensismentioning

confidence: 99%

Untitled

2023

IJPSR

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The rising burden of cancer worldwide calls for an indispensable treatment result. Herbal drug provides a veritably doable volition to western drug against cancer. This composition reviews the named plant species with active phytochemicals, the animal models used for these studies, and their nonsupervisory aspects. This study is grounded on a scrupulous literature review conducted through the hunt of applicable keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty shops were named grounded on defined selection criteria for their potent anticancer composites. The detailed analysis of the exploration studies revealed that plants play a necessary part in fighting different cancers similar as bone, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in-vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis-converting enzymes by the secondary metabolites in the plant excerpts. Studies that reported in-vivo conditioning of these plants showed remarkable results in the inhibition of cancer in animal models. Further studies should be performed on exploring further plants, their active composites, and the medium of anticancer conduct for use as standard herbal drug. INTRODUCTION:The burden of cancer rose to 18.1 million new cases and 9.6 million deaths in 2018. With 36 different types, cancer mainly affects men in the form of colorectal, liver, lung, prostate, and stomach cancer and women in the form of breast, cervix, colorectal, lung, and thyroid cancer 1 . Treating cancer has come a whole new area of exploration. There are conventional as well as truly modern ways applied against cancers. A variety of ways i.e., chemotherapy, radiation remedy, or surgery are used for treating cancer. Still, all of them have some disadvantages 2 . The use of conventional chemicals bears side goods and venom 3 .

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“…Trabalhos experimentais têm reportado o uso de hidróxido de sódio ou hidróxido de cálcio no pré-tratamento de materiais lignocelulósicos e afirmam que melhora o rendimento nas próximas etapas (PARK et al, 2010).…”

Section: Pré-tratamento Alcalinounclassified

Fitoquímica: potencialidades biológicas dos biomas brasileiros

Miranda¹

2022

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Parecer e revisão por paresOs textos que compõem esta obra foram submetidos para avaliação do Conselho Editorial da Editora Científica Digital, bem como revisados por pares, sendo indicados para a publicação.O conteúdo dos capítulos e seus dados e sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores e autoras.É permitido o download e compartilhamento desta obra desde que pela origem da publicação e no formato Acesso Livre (Open Access), com os créditos atribuídos aos autores e autoras, mas sem a possibilidade de alteração de nenhuma forma, catalogação em plataformas de acesso restrito e utilização para fins comerciais.Esta obra está licenciada com uma Licença Creative Commons Atribuição-Não Comercial-Sem Derivações 4.0 Internacional (CC BY-NC-ND 4.0). Dados Internacionais de Catalogação na Publicação (CIP) F546Fitoquímica: potencialidades biológicas dos biomas brasileiros / Mayker Lazaro Dantas Miranda (Organizador). -Guarujá-SP: Científica Digital, 2022.

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Anticancer activity of 28-Oxoallobetulin on HT-29 human colon cancer cells

Cited by 7 publications

References 20 publications

Anti-Colorectal Cancer Effects of Fucoidan Complex-Based Functional Beverage Through Retarding Proliferation, Cell Cycle and Epithelial–Mesenchymal Transition Signaling Pathways

Anti-Colorectal Cancer Effects of Fucoidan Complex-Based Functional Beverage Through Retarding Proliferation, Cell Cycle and Epithelial–Mesenchymal Transition Signaling Pathways

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Fitoquímica: potencialidades biológicas dos biomas brasileiros

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