Anticancer activity of a series of copper(II) complexes with tripodal ligands

Isoxazole‐Derived Aroylhydrazones and Their Dinuclear Copper(II) Complexes Show Antiproliferative Activity on Breast Cancer Cells with a Potentially Alternative Mechanism Of Action

“…Cu1-O2 distances (Å): (1) 1.8996 (20) and 41.9606 (14). Cu2-O2 distances (Å): (1) 2.3051 (16) and (4) 2.3801 (15). and selected geometric parameters for complexes 1 and 4 are shown in Table S6).…”

“…[14] Mononuclear copper (II) complexes of pyridine containing tetradentate tripodal N,N,N ligands were also shown to display moderate cytotoxicity on cancer cell lines albeit not much different from that of the ligands alone. [15,16] As part of a research program initially aimed at developing small molecular mimics of dinuclear metalloenzymes such as purple acid phosphatases (PAPs), containing a Fe/M cluster (M=Fe, Zn, or Mn) or catechol oxidases (COs), which are type-3 copper enzymes, a full series of dinuclear coordination compounds were systematically prepared and studied. [17][18][19][20][21][22][23][24] In the latter case, a symmetrical binucleating Schiff base ligand with a central phenol group mimicking the coordination sphere of the two copper ions in the enzyme was introduced.…”

Synthesis, Spectral and Thermal Characterization of Cu(II) Complexes Containing Schiff Base Ligands and Their Antibacterial Activity Study

“…The free Schiff base ligand and their metal complexes were screened for their antibacterial activity against strains the Bacillus cereus ATCC25923, Escherichia coli ATCC 25922, Shigella sonnei, Shigella boydii, Enterobacter, Salmonella typhinium of 4500. The compounds were tested at a concentration of 50 µg/ 0.01 mL in DMSO solution using the paper disc diffusion method [8,10,[23][24][25]. The susceptibility zones were measured in diameter (mm) and the result were listed in table 7.…”

Theoretical and experimental investigation of anticancer activities of an acyclic and symmetrical compartmental Schiff base ligand and its Co(ii), Cu(ii) and Zn(ii) complexes

“…In addition to the expected biological properties of the Schiff base compounds, [30][31][32][33][34][35] binding the cobalt, copper and zinc atoms to this unit make these complexes a good prospect for biologically active compounds [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] (31)(32)(33)(34)(35) for zinc, 36-40 for cobalt, 41-45 for copper). For the study of the biological activities of new ligand (H 3 L Br ) and its complexes 1-3, docking calculations were run to investigate the possibility of interaction between these compounds with nine protein targets, including: BRAF kinase, cathepsin B (CatB), DNA gyrase, histone deacetylase (HDAC7), recombinant human albumin (rHA), ribonucleotide reductases (RNR), thioredoxin reductase (TrxR), thymidylate synthase (TS), topoisomerase II (Top II).…”