Anticancer activity of a sub-fraction of dichloromethane extract of Strobilanthes crispus on human breast and prostate cancer cells in vitro

Yaacob, Nik Soriani; Hamzah, Nurraihana; Kamal, Nik Nursyazni Nik Mohamed; Abidin, Siti Amalina Zainal; Lai, Choon Sheen; Navaratnam, V.; Nor, Norazmi Mohd

doi:10.1186/1472-6882-10-42

Cited by 73 publications

(73 citation statements)

References 27 publications

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“…Cancer is a major public health problem worldwide with millions of new cancer patients diagnosed each year and many deaths resulting from this disease (Barbaric et al, 2010;Yaacob et al, 2010). Breast cancer is the second most diagnosed cancer worldwide with a total of 1.38 million cases (Cleary et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Change in Adiponectin and Oxidative Stress after Modifiable Lifestyle Interventions in Breast Cancer Cases

Karimi

Roshan²

2013

Asian Pacific Journal of Cancer Prevention

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Background: Breast cancer is one of the most frequent diseases in women today. Little information exists on modifiable lifestyle factors including effects of ginger supplements (as an anti-oxidant and anti-inflammatory herbal) and water-based exercise on biomarkers related to oxidative stress such as malondialdehyde (MDA), nitric oxide (NO) and glutathione peroxidase (GPx) and adiponectin in obese women with breast cancer. The aim of this study was to determine the single and concomitant effect of 6-wks water-based exercise and oral ginger supplement on the aforesaid markers in obese women with breast cancer. Materials and Methods: Forty women diagnosed with breast cancer (48±5.4 years, 76±9 kg, fat mass 41.8±4%), volunteered to participate in the study. Subjects were randomly assigned into four groups; placebo, water-based exercise, ginger supplement and water-based exercise+ginger supplement groups. Subjects in the ginger supplement group and the water-based exercise+ginger supplement group orally received 4 capsules (each capsule contained 750 mg), 7 days a week for 6 weeks. The water-based exercise program featured progressive increase in intensity and time, ranging from 50% to 75% of heart rate reserve, in a pool with 15 meters width, 4 times a week for 6 weeks. Fasting blood samples were collected at pre-test and post-test time points. Results: The ginger supplementation and or the water-base exercise resulted in an increase of adiponectin, NO and GPx and reduction MDA, as compared to pre-test values. However, the combined intervention (water-base exercise and ginger supplement) group showed significantly a far better effect on the biomarkers related to oxidative stress and adiponectin levels, as compared to the waterbase exercise or ginger supplement alone groups and the age-matched placebo group. Conclusions: Our results revealed that water-base exercise is a non-drug therapeutic strategy to reduce systemic stress in obese women suffering from breast cancer. Further, ginger supplementation alone or in combination with training, also play an important role in the pathogenesis of oxidative stress in obese women diagnosed with breast cancer.

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Section: Introductionmentioning

confidence: 99%

Change in Adiponectin and Oxidative Stress after Modifiable Lifestyle Interventions in Breast Cancer Cases

Karimi

Roshan²

2013

Asian Pacific Journal of Cancer Prevention

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“…A previous study demonstrated that S. crispa leaves possess anti-diabetic, diuretic and blood pressure lowering properties (17). Furthermore, a number of studies have recorded the potency of S. crispa extracts in inhibiting cancer cell growth (22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Anticancer mechanisms of Strobilanthes crispa Blume hexane extract on liver and breast cancer cell lines

et al. 2017

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Abstract. Cancer is a major public health concern not only in developed countries, but also in developing countries. It is one of the leading causes of mortality worldwide. However, current treatments may cause severe side effects and harm. Therefore, recent research has been focused on identifying alternative therapeutic agents extracted from plant-based sources in order to develop novel treatment options for cancer. Strobilanthes crispa Blume is a plant native to countries including Madagascar and Indonesia. It has been used as an anti-diabetic, diuretic and laxative in traditional folk medicine. Furthermore, S. crispa has potential in treating cancer, as evidenced in previous studies. In the present study, the cytotoxic and apoptotic activities of S. crispa crude extracts were investigated in liver and breast cancer cell lines. Hexane, ethyl acetate, chloroform, methanol and water extracts prepared from the leaves, and stems of S. crispa were evaluated for their cytotoxicity on HepG-2 and MDA-MB-231 cells using an MTT assay. The anti-proliferative properties of stem hexane (SH) extract on both cell lines were analysed using cell doubling time determination and cell cycle analysis, while the apoptogenic properties was determined through the detection of caspase-8. Among the extracts tested, SH extract exhibited the lowest half maximal inhibitory concentrations in both the cell lines. The SH extract induced morphological changes in HepG-2 and MDA-MB-231 cells, and significantly delayed cell population doubling time. Furthermore, it altered cell cycle profile and significantly increased caspase-8 activity in HepG-2 cells, but not in MDA-MB-231 cells. In conclusion, the SH extract of S. crispa possesses potent anticancer properties and may be a suitable chemotherapeutic target. IntroductionCancer is characterized by uncontrolled growth and spreading of abnormal cells. It is one of the most life-threatening and challenging diseases of modern time, caused by a number of internal factors, including immune condition and inherited mutation, and external factors, including radiation, tobacco and chemical exposure (1). Liver, breast, colorectal, lung, cervical and nasopharyngeal cancer are the most prevalent cancer types in the modern age. The present study focused on liver and breast cancer due to their high occurrence rates. In 2006, hepatocellular carcinoma (HCC) was identified to account for 70-85% of total primary liver cancer types (2). HCC is primarily caused by chronic viral hepatitis B or C infection, iron overload, aflotoxin exposure, obesity, alcohol-associated cirrhosis and possibly non-alcoholic fatty liver disease (3,4). Breast cancer continues to be the leading cause of cancer-associated mortality among women (5), and the occurrence rate has increased in China and other Asian countries (6,7). Breast cancer can be categorized into two main types, ductal carcinoma and lobular carcinoma. Ductal carcinoma begins in the ducts that transport milk from the breast to the nipple, whereas lobular carcinoma starts i...

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“…Several authors have investigated the effects of phytochemicals on TP53 gene expression as a measure of apoptosis induction in cell lines (Azizi et al, 2009;Yaacob et al, 2010;Wang and Sun, 2010;Alshatwi et al, 2011;Alshehri and Elsayed, 2012). It is well known that p53 acts biochemically as a transcription factor and biologically as a powerful tumor suppressor.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of retinoblastoma (Rb) and protein-53 (p53) gene expression levels in breast cancer cell lines (MCF-7) induced with some selected cytotoxic plants

Aderonke¹,

Ayorinde²,

Adesola³

et al. 2013

J. Pharmacognosy Phytother.

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Anticancer activity of a sub-fraction of dichloromethane extract of Strobilanthes crispus on human breast and prostate cancer cells in vitro

Cited by 73 publications

References 27 publications

Change in Adiponectin and Oxidative Stress after Modifiable Lifestyle Interventions in Breast Cancer Cases

Change in Adiponectin and Oxidative Stress after Modifiable Lifestyle Interventions in Breast Cancer Cases

Anticancer mechanisms of Strobilanthes crispa Blume hexane extract on liver and breast cancer cell lines

Evaluation of retinoblastoma (Rb) and protein-53 (p53) gene expression levels in breast cancer cell lines (MCF-7) induced with some selected cytotoxic plants

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