Anticancer Activity of Dinitrosyl Iron Complex (NO Donor) on the Multiple Myeloma Cells

Akentieva, Natalia; Sanina, Nataliya A.; Prichodchenko, T. R.; Gizatullin, A. R.; Shkondina, N. I.; Шушанов, С. С.; Stupina, Tatyana S.; Алдошин, С. М.

doi:10.1134/s1607672919030190

Cited by 10 publications

(6 citation statements)

References 12 publications

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“…Our study confirms the findings obtained by other researchers concerning the ability of M-DNIC and B-DNIC with thiol-containing ligands to exert cytotoxic activity toward transformed cells [14,[33][34][35]. It should be noted here that these complexes could well exert this activity toward the normal cells [15,30,31].…”

Section: Discussionsupporting

confidence: 92%

“…It should be noted that DNIC with thiol-containing ligands can exert the antiapoptotic activity as well as the proapoptotic activity demonstrated in this work and elsewhere [14,15,30,31,[33][34][35]. The antiapoptotic activity was shown for endogenous DNIC with thiol-containing ligands produced in animal cells upon elevation of nonheme iron and NO generation [9].…”

Section: −•supporting

confidence: 66%

“…Upon a subsequent elevation of DNIC concentration in a cell culture medium, S-nitrosylation of the surface proteins caused by these complexes became crucial for DNIC proapoptotic activity. Thus, the results obtained in this work and elsewhere [14,15,30,31,[33][34][35] as well as the data from [9] enrich rather than contradict each other.…”

Section: −•supporting

confidence: 63%

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Nitrosonium Cation as a Cytotoxic Component of Dinitrosyl Iron Complexes with Thiol-containing Ligands (based on the Experimental Work on MCF7 Human Breast Cancer Cell Culture)

Vanin

Tronov

Borodulin

2021

Cell Biochem Biophys

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Here we demonstrate that binuclear dinitrosyl iron complexes with thiol-containing ligands (glutathione and mercaptosuccinate, B-DNIC-GSH and B-DNIC-MS, respectively) exert cytotoxic effects on MCF7 human breast cancer cells. We showed that they are mediated by nitrosonium cations released from these complexes (NO + ). This finding is supported by the cytotoxic effect of both B-DNICs on MCF7 cells evidenced to retain or was even promoted in the presence of N-Methyl-D-glucamine dithiocarbamate (MGD). MGD recruits an iron nitrosyl group [Fe(NO)] from the iron-dinitrosyl fragment [Fe(NO) 2 ] of B-DNIC-MS forming stable mononitrosyl complexes of iron with MGD and releasing NO + cations from a [Fe(NO) 2 ] fragment.

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Section: Discussionsupporting

confidence: 92%

Section: −•supporting

confidence: 66%

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Nitrosonium Cation as a Cytotoxic Component of Dinitrosyl Iron Complexes with Thiol-containing Ligands (based on the Experimental Work on MCF7 Human Breast Cancer Cell Culture)

Vanin

Tronov

Borodulin

2021

Cell Biochem Biophys

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“…Liaw, Wang and coworkers answered the call and synthesized a water-soluble neutral DNIC, [(S(CH 2 ) 2 OH)(S(CH 2 ) 2 NH 3 )Fe(NO) 2 ] ( 59 ), that causes antitumor activity via apoptosis in prostate cancer, breast cancer and non-small cell lung cancer cell lines . Other synthetic complexes were prepared by Aldoshin and coworkers, including a thiourea based complex, [(SC(NHCH 3 ) 2 ) 2 Fe(NO) 2 ] ( 84 ), that shows cytotoxic effects on human multiple myeloma cells by decreasing intracellular glutathione concentrations and increasing the level of reactive oxygen species, most notably peroxynitrite …”

Section: Dinitrosyl Iron Complexes (Dnics)mentioning

confidence: 99%

The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity

et al. 2021

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Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of physiological and pathological events in biology. Metal coordination chemistry, especially with iron, is at the heart of many biological transformations involving NO. A series of heme proteins, nitric oxide synthases (NOS), soluble guanylate cyclase (sGC), and nitrophorins, are responsible for the biosynthesis, sensing, and transport of NO. Alternatively, NO can be generated from nitrite by heme- and copper-containing nitrite reductases (NIRs). The NO-bearing small molecules such as nitrosothiols and dinitrosyl iron complexes (DNICs) can serve as an alternative vehicle for NO storage and transport. Once NO is formed, the rich reaction chemistry of NO leads to a wide variety of biological activities including reduction of NO by heme or non-heme iron-containing NO reductases and protein post-translational modifications by DNICs. Much of our understanding of the reactivity of metal sites in biology with NO and the mechanisms of these transformations has come from the elucidation of the geometric and electronic structures and chemical reactivity of synthetic model systems, in synergy with biochemical and biophysical studies on the relevant proteins themselves. This review focuses on recent advancements from studies on proteins and model complexes that not only have improved our understanding of the biological roles of NO but also have provided foundations for biomedical research and for bio-inspired catalyst design in energy science.

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“…15,16 The salt forms of DNICs, as less toxic and more bioavailable complexes of this family, were obtained using thio derivatives of nucleobases 17 and aliphatic thioureas as sulfur containing ligands. 18,19 The cytotoxicity of these DNICs has been studied in tumor cells of various origins, including ovarian cancer (SKOV3), colon cancer (LS174T) and non-small cell lung cancer (A549), 17 cervical carcinoma (HeLa) and breast cancer (MCF-7), 18 as well as multiple myeloma. 19 A DNIC with an N′ethylthiourea ligand was mildly toxic to most cell lines studied except the human glioblastoma cell line A-172 that proved to be highly sensitive to the complex.…”

Section: Introductionmentioning

confidence: 99%

Cationic dinitrosyl iron complexes with thiourea exhibit selective toxicity to brain tumor cells in vitro

et al. 2022

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Anticancer Activity of Dinitrosyl Iron Complex (NO Donor) on the Multiple Myeloma Cells

Cited by 10 publications

References 12 publications

Nitrosonium Cation as a Cytotoxic Component of Dinitrosyl Iron Complexes with Thiol-containing Ligands (based on the Experimental Work on MCF7 Human Breast Cancer Cell Culture)

Nitrosonium Cation as a Cytotoxic Component of Dinitrosyl Iron Complexes with Thiol-containing Ligands (based on the Experimental Work on MCF7 Human Breast Cancer Cell Culture)

The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity

Cationic dinitrosyl iron complexes with thiourea exhibit selective toxicity to brain tumor cells in vitro

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